NSAIDS and RA and OA management

Question 1

NSAIDS work by interfering with the synthesis of an endogenous compound called _____ by inhibiting ____ enzyme

Answer 1

prostaglandins, cyclooxygenase (COX)

Question 2

____ enzyme produces prostaglandins that help regulate normal cell activity and maintain cell homeostasis
____ enzyme is produced primarily in injured cells

Answer 2

COX-1, COX-2

Question 3

Which NSAID is associated with Reye syndrome in kids that can cause delirium, coma and even death?

Answer 3

aspirin

Question 4

T/F acetaminophen can be used for treating inflammatory disorders

Answer 4

false, cannot be used for that, only for non-inflammatory disorders

Question 5

What three categories can be used to treat RA?

Answer 5

NSAIDS, glucocorticoids/corticosteroids, disease-modifying antirheumatic drugs (dmards)

Question 6

When are glucocorticoids used in treating RA?

Answer 6

can be used during acute flare-ups or exacerbations of RA, and can be injected directly into the joint in order to manage exacerbations

Question 7

What are some adverse effects you need to be aware of with someone who is taking glucocosteroids

Answer 7

risk of osteoporosis, mm wasting and weakness, aggravation of DM

Question 8

What medications are used to halt or slow the progression of RA?

Answer 8

DMARDS

Question 9

Antimalarials are a group of nonbiological traditional DMARDS used when pts cannot tolerate others, what do you have to be aware of in these patients?

Answer 9

recommend regular eye exams for patients as high doses can cause irreversible retinal damage

Question 10

Which RA drug is also used to treat cancer and has a greater therapeutic effect?

Answer 10

methotrexate

Question 11

t/f, gold therapy is only used for patients who do not respond to other DMARDS

Answer 11

true, it suppresses the immune system and helps manage RA

Question 12

t/f, tumor necrosis factors inhibitors are not contraindicated for patients with RA and who have a current infection

Answer 12

false, it is contraindicated in this case

Question 13

T/F, some RA sx can be reduced through diet high in fish oil and omega-3 fatty acids

Answer 13

true, and diets high in meat and protein can exacerbate symptoms

Question 14

Which disease modifying OA drug uses hyaluronic acid to restore the lubricating properties of synovial fluid in arthritic joints?

Answer 14

viscosupplementation

Question 15

Which dietary supplements may help protect articular cartilage or reverse the joint deterioration found in OA?

Answer 15

glucosamine and chondroitin sulfate

Question 16

t/f, aspirin and nsaids can inhibit bone healing

Answer 16

true, can inhibit it

Question 17

Which pain medications affect the kidneys?

Answer 17

nsaids and aspirin

Question 18

Which pain medication has sedative properties and causes slowed breathing rate?

Answer 18

opiods

Question 19

t/f, nsaids decrease BP

Answer 19

false, increase BP

Question 20

A pt presents with HA, tinnitus, difficulty hearing, confusion, and metabolic acidosis, they state they have been taking aspirin, what are you concerned about?

Answer 20

that the patient has aspirin poisoning