NSAIDS Flashcards
where can NSAIDs cause ulceration and bleeding
GI tract
what kind of toxicity can NSAIDs cause
hepatotoxicity
nephrotoxicity
what can NSAIDs inhibit
cartilage metabolism
Platelet aggregation
what can NSAIDs suppress
bone marrow
what enzyme do NSAIDs block
cyclooxygenase (COX 1 and COX 2)
what enzyme do glucocorticoids block
phospholipase
use NSAIDs with caution in what kind of patients
geriatric
do not combine NSAIDs with what other kind of drugs
corticosteroids
what should you tell clients may be a side effects of NSAIDs (3 things)
**Anorexia
Vomiting
Changes in bowel movements
two reasons why cats are particularly sensitive to NSAIDs
very long half life (days)
not well metabolized by the liver
one dose of what pain drug can be fatal to cats
acetaminophen
the only three pain drugs that can be used in cats
Onsior
Metacam
Solensia
how is Onsior adminstered to cats and how long can it be given
orally
up to three days
how is Metacam administered to cats and how long can it be given
SQ injection
one injection only
how is Solensia administered to cats and how often is it given
injection
monthly
what kind of NSAID is Aspirin
salicylate
what is aspirin also know as
Acetylsalicylic Acid (ASA)
what does aspirin inhibit
platelet aggregation (good for humans, bad for dogs!)
how should aspirin be used
short term, specific use
what can result from long term aspirin use
degeneration of cartilage
what must you do if you want to transition from aspirin to another NSAID
have a washout period
what NSAID is called “Bute”
Phenylbutazone (not butorphanol!)
what species is Phenylbutazone mainly used in and for what two issues
equine
lameness and colic
what can perivascular administration of phenylbutazone cause
tissue death and sloughing
Brand name of Flunixin Meglamine
Banamine
what species is Banamine used in
horses and cattle
A clear, smelly liquid (solvent)
Dimethyl sulfoxide (DMSO)
what can Dimethyl sulfoxide (DMSO) do to the skin
it’s a solvent and can carry other agents through the skin
why is Dimethyl sulfoxide (DMSO) not very common anymore
can be hazardous, wear gloves!
which is better for dogs, but still not safe!
ibuprofen or acetaminophen
acetaminophen
three uses of NSAIDs in small animals
Canine OSTEOARTHRITIS management
POST-operative pain
Other analgesic action
three dangers of chronic NSAID use
GI upset and ulceration
Liver disease
Cartilage damage
what pain reliever is in wafer form
Zubrin (Tepoxalin)
what pathway does Zubrin (Tepoxalin) use
Lipoxygenase
frequently causes GI bleeding and ulcers in horses (but it’s cheap and readily available)
Phenylbutazone (Bute paste)
causes severe tissue damage if administered perivascularly, SQ, or IM
Phenylbutazone (Bute paste)
