NSAIDS

Question 1

where can NSAIDs cause ulceration and bleeding

Answer 1

GI tract

Question 2

what kind of toxicity can NSAIDs cause

Answer 2

hepatotoxicity
nephrotoxicity

Question 3

what can NSAIDs inhibit

Answer 3

cartilage metabolism
Platelet aggregation

Question 4

what can NSAIDs suppress

Answer 4

bone marrow

Question 5

what enzyme do NSAIDs block

Answer 5

cyclooxygenase (COX 1 and COX 2)

Question 6

what enzyme do glucocorticoids block

Answer 6

phospholipase

Question 7

use NSAIDs with caution in what kind of patients

Answer 7

geriatric

Question 8

do not combine NSAIDs with what other kind of drugs

Answer 8

corticosteroids

Question 9

what should you tell clients may be a side effects of NSAIDs (3 things)

Answer 9

**Anorexia
Vomiting
Changes in bowel movements

Question 10

two reasons why cats are particularly sensitive to NSAIDs

Answer 10

very long half life (days)
not well metabolized by the liver

Question 11

one dose of what pain drug can be fatal to cats

Answer 11

acetaminophen

Question 12

the only three pain drugs that can be used in cats

Answer 12

Onsior
Metacam
Solensia

Question 13

how is Onsior adminstered to cats and how long can it be given

Answer 13

orally

up to three days

Question 14

how is Metacam administered to cats and how long can it be given

Answer 14

SQ injection

one injection only

Question 15

how is Solensia administered to cats and how often is it given

Answer 15

injection

monthly

Question 16

what kind of NSAID is Aspirin

Answer 16

salicylate

Question 17

what is aspirin also know as

Answer 17

Acetylsalicylic Acid (ASA)

Question 18

what does aspirin inhibit

Answer 18

platelet aggregation (good for humans, bad for dogs!)

Question 19

how should aspirin be used

Answer 19

short term, specific use

Question 20

what can result from long term aspirin use

Answer 20

degeneration of cartilage

Question 21

what must you do if you want to transition from aspirin to another NSAID

Answer 21

have a washout period

Question 22

what NSAID is called “Bute”

Answer 22

Phenylbutazone (not butorphanol!)

Question 23

what species is Phenylbutazone mainly used in and for what two issues

Answer 23

equine

lameness and colic

Question 24

what can perivascular administration of phenylbutazone cause

Answer 24

tissue death and sloughing

Question 25

Brand name of Flunixin Meglamine

Answer 25

Banamine

Question 26

what species is Banamine used in

Answer 26

horses and cattle

Question 27

A clear, smelly liquid (solvent)

Answer 27

Dimethyl sulfoxide (DMSO)

Question 28

what can Dimethyl sulfoxide (DMSO) do to the skin

Answer 28

it’s a solvent and can carry other agents through the skin

Question 29

why is Dimethyl sulfoxide (DMSO) not very common anymore

Answer 29

can be hazardous, wear gloves!

Question 30

which is better for dogs, but still not safe!

ibuprofen or acetaminophen

Answer 30

acetaminophen

Question 31

three uses of NSAIDs in small animals

Answer 31

Canine OSTEOARTHRITIS management
POST-operative pain
Other analgesic action

Question 32

three dangers of chronic NSAID use

Answer 32

GI upset and ulceration
Liver disease
Cartilage damage

Question 33

what pain reliever is in wafer form

Answer 33

Zubrin (Tepoxalin)

Question 34

what pathway does Zubrin (Tepoxalin) use

Answer 34

Lipoxygenase

Question 35

frequently causes GI bleeding and ulcers in horses (but it’s cheap and readily available)

Answer 35

Phenylbutazone (Bute paste)

Question 36

causes severe tissue damage if administered perivascularly, SQ, or IM

Answer 36

Phenylbutazone (Bute paste)