Norepinephrine (Infusion Pump Only)

Question 1

NOREPINEPHRINE (INFUSION PUMP ONLY)

Pharmacology & Actions

Answer 1

• Catecholamine that stimulates beta-1 and alpha-1 receptors in sympathetic nervous system
• Results in vasoconstriction, increased blood pressure, enhanced contractility, and increased heart rate

Question 2

NOREPINEPHRINE (INFUSION PUMP ONLY)

Indications

Answer 2

• Hypotension unresponsive to IV fluid resuscitation

Question 3

NOREPINEPHRINE (INFUSION PUMP ONLY)

Absolute Contraindications

Answer 3

• Hypotension caused by hypovolemia (blood volume deficit)
• Norepinephrine allergy

Question 4

NOREPINEPHRINE (INFUSION PUMP ONLY)

Precautions & Side Effects

Answer 4

• Ensure adequate fluid replacement before starting norepinephrine
• Administer through largest vein possible to reduce risk of tissue necrosis if it extravasates
• Monitor blood pressure closely
• Must be administered via infusion pump

Question 5

NOREPINEPHRINE (INFUSION PUMP ONLY)

Administration

Answer 5

• IV (Infusion Pump Only)
• Onset: Immediate
• Peak Effect: < 1min
• Duration: 1-2min