Lorazepam (Ativan)

Question 1

LORAZEPAM (ATIVAN)

Pharmacology & Actions

Answer 1

• Benzodiazepine that functions as a CNS depressant, anticonvulsant, and sedative

Question 2

LORAZEPAM (ATIVAN)

Indications

Answer 2

• Seizures
• Sedation
• Agitation/excited delirium
• Uncontrolled shivering in hyperthermia

Question 3

LORAZEPAM (ATIVAN)

Absolute Contraindications

Answer 3

• Neurologic or respiratory depression
• Acute angle glaucoma
• Lorazepam allergy

Question 4

LORAZEPAM (ATIVAN)

Precautions & Side Effects

Answer 4

• Respiratory depression and/or hypotension can occur, the patient should be monitored closely
• Most likely to produce respiratory depression in patients who have taken other depressant drugs, especially alcohol and barbiturates, or when given rapidly
• Elderly patients may have more profound respiratory and/or CNS depression, half dose should be adminsitered

Question 5

LORAZEPAM (ATIVAN)

Administration

Answer 5

• IV/IO
  
  • Onset: 1-2min
  • Peak: <15min
  • Duration: 6-8hrs
• IM
  
  • Onset: 15-30min
  • Peak: 2-3hrs
  • Duration: 6-8hrs

Question 6

LORAZEPAM (ATIVAN)

Dosage

Answer 6

• Seizures dosage
• 0.1mg/kg
  
  • Max dose of 4mg
  • Administer slowly over 2 min