Non-opioid analgesics

Question 1

First gen COX 1 action?

Answer 1

Inhibition of COX-1 can result in decreased platelet aggregation and kidney damage
- inhibition of prostaglandin synthesis

Question 2

Second gen Cox-2 inhibitors

Answer 2

• Celecoxib
• inhibition of COX2 results in decreased inflammation, fever, and pain and does not decrease platelet aggregation

Question 3

NSAID uses?

Answer 3

• inflammation suppression
• analgesia for mild to moderate pain
• fever reduction
• Dysmenorrhea
• inhibition of platelet aggregation which prevents against ischemic stroke

Question 4

NSAID Complications?

Answer 4

• dyspepsia
• abdominal pain
• Bleeding
• heart burn
• Nausea