non-neoplastic disorders

Question 1

what do you expect to see in a blood film when there a person is going through inflammation (broad)?

Answer 1

• neutrophilia w/ left shift

- reactive lymphocytes

Question 2

what do you expect to see in a blood film in a person w/ appendicitis?*

Answer 2

• increasing mean of WBC in different stages
• changes in WBC numbers because don’t know if reserve in bone marrow is overwhelmed or cells have not moved into circulation yet

Question 3

What do you expect to see in a blood film in a person w/ sepsis?

Answer 3

• left shift
• Dohle bodies
• Toxic granulation
• vacuolation
• microorganisms
• inc. WBC, neutrophils => neutropenia bc BM overworked producing cells

Question 4

what do you expect to see in a blood film in a person with systemic inflammatory response syndrome?

Answer 4

• increase WBC, neutrophils *but if WBC are w/in normal may be bc BM has slowed down in production bc BM exhausted
• left shift

Question 5

what do you expect to see in a blood film in a person with infectious mononucleosis?

Answer 5

• lymphocytosis: >50%

- reactive lymphocytes

Question 6

In what cases woud you exect to see reactive lymphocytes

Answer 6

• viral disease
• bacterial disease
• antigenic stimulation e.g. vaccinations

Question 7

what are the 4 congenital (present @ birth) disorders of leukocytes? & e.g.

Answer 7

1. Adhesion defects (e.g. leukocyte adhesion deficiency)
2. Granule defects (e.g. Chediak-higasi granules)
3. Chemotactic defects (e.g. “-“ “)
4. Phagocytotic defect (e.g. “-“ “)

Question 8

What do chediak-higashi granules look like in what cells? what does this mean?

Answer 8

• large grey/blue granules
• in neutrophil, platelets, monocytes
• => dysfunctional granules = can’t form phagolysosome = dysfunctional bacteriocidal activity

Question 9

What is/are the causes of acquired (develop over time) disorders of leukocytes? (like adhesion, chemotactic, pahocytic defects)

Answer 9

Diabetes mellitus