Non covalent Bonding Flashcards
Describe kekuke structure
Shows bonding without Lewis bases
Describe condensed structure
Shows formula egCh4
Describe skeeltal structure
Just lines showing no carbon or hydrogen
How man hydrogen can c bond to
4
How do you work out molar mass of structures
No of different atoms (e.gcarbons) x big number on periodic table
What do main macromolecules target
Proteins + nucleic acids
Describe the interaction of drug with target in relation to shape
Bind to specific binding site
How do drugs bind to targets
Forming intermolecular interactions non covalent bonds
Describe the interaction between macromolecule target and drug
Drug is smaller than target, entering hydrophobic hollow cleft, via process of induced fit
Is there equillibrium between bound and unbound target
Yes
Why is the process of binding induced fit
Binding site changes shape for drug to fit
What is the functional group on drug
Binding group
What is the area of target on binding site
Binding region
What do several amino acids form
Polypeptide chain
What is the aa r group determine
Protein side chain determining type of interactio
Whats the effect if an induced fit
Changes overall shape of drug target for a better pharma interaction
Describe electrostatic ionic bonding
Important initial interaction
Opposite ion charges bond
Strongest interaction
Long range interaction
20-40
Describe van der waals interaction
Occur between hydrophobic regions
There are temperary areas of high and low electrons which form dipoles = bonding
Short range interaction therefore drug myst be close
What two things have to be present for hydrogen bonding
E deficient hydrogen
E rich heteroatom
What is the interaction between electron deficient hydrogen and e rich heteroatom
They attach
What does the electron deficient hydrogen act as
Hydrogen bond donor
What does the electron rich heteroatom act as
Hydrogen bond acceptor
Which functional groups act as good HBAs + HBD
Hydroxide and amine
What makes a good HBA
Electronegative
Lone pair of e
Explain the relationship between density of heteroatom and strength of HBA
As one increases so does the second
Give examples of good HBAs
CO2 & PO3
What makes a moderate hba
Cooh oh o n
This is because e density diffuses
What makes a weak hba
Triple bonds
Cl
F
S
This is because of lone pairs in third shell
What is a dipole dipole interaction
Occur if drug binding sige have dipole moments
Dipoles align and bond
(Arrows in dipole)
Whats the difference between dipole dipole and van der walls
Dipol- localised
Van - transient
What is an ion dipole interaction
Ion on 1 molecule interacts with dipole moment of other
Stronger than dipole dipole
