Non covalent Bonding

Question 1

Describe kekuke structure

Answer 1

Shows bonding without Lewis bases

Question 2

Describe condensed structure

Answer 2

Shows formula egCh4

Question 3

Describe skeeltal structure

Answer 3

Just lines showing no carbon or hydrogen

Question 4

How man hydrogen can c bond to

Answer 4

4

Question 5

How do you work out molar mass of structures

Answer 5

No of different atoms (e.gcarbons) x big number on periodic table

Question 6

What do main macromolecules target

Answer 6

Proteins + nucleic acids

Question 7

Describe the interaction of drug with target in relation to shape

Answer 7

Bind to specific binding site

Question 8

How do drugs bind to targets

Answer 8

Forming intermolecular interactions non covalent bonds

Question 9

Describe the interaction between macromolecule target and drug

Answer 9

Drug is smaller than target, entering hydrophobic hollow cleft, via process of induced fit

Question 10

Is there equillibrium between bound and unbound target

Answer 10

Yes

Question 11

Why is the process of binding induced fit

Answer 11

Binding site changes shape for drug to fit

Question 12

What is the functional group on drug

Answer 12

Binding group

Question 13

What is the area of target on binding site

Answer 13

Binding region

Question 14

What do several amino acids form

Answer 14

Polypeptide chain

Question 15

What is the aa r group determine

Answer 15

Protein side chain determining type of interactio

Question 16

Whats the effect if an induced fit

Answer 16

Changes overall shape of drug target for a better pharma interaction

Question 17

Describe electrostatic ionic bonding

Answer 17

Important initial interaction
Opposite ion charges bond
Strongest interaction
Long range interaction
20-40

Question 18

Describe van der waals interaction

Answer 18

Occur between hydrophobic regions
There are temperary areas of high and low electrons which form dipoles = bonding
Short range interaction therefore drug myst be close

Question 19

What two things have to be present for hydrogen bonding

Answer 19

E deficient hydrogen
E rich heteroatom

Question 20

What is the interaction between electron deficient hydrogen and e rich heteroatom

Answer 20

They attach

Question 21

What does the electron deficient hydrogen act as

Answer 21

Hydrogen bond donor

Question 22

What does the electron rich heteroatom act as

Answer 22

Hydrogen bond acceptor

Question 23

Which functional groups act as good HBAs + HBD

Answer 23

Hydroxide and amine

Question 24

What makes a good HBA

Answer 24

Electronegative
Lone pair of e

Question 25

Explain the relationship between density of heteroatom and strength of HBA

Answer 25

As one increases so does the second

Question 26

Give examples of good HBAs

Answer 26

CO2 & PO3

Question 27

What makes a moderate hba

Answer 27

Cooh oh o n
This is because e density diffuses

Question 28

What makes a weak hba

Answer 28

Triple bonds
Cl
F
S
This is because of lone pairs in third shell

Question 29

What is a dipole dipole interaction

Answer 29

Occur if drug binding sige have dipole moments
Dipoles align and bond
(Arrows in dipole)

Question 30

Whats the difference between dipole dipole and van der walls

Answer 30

Dipol- localised
Van - transient

Question 31

What is an ion dipole interaction

Answer 31

Ion on 1 molecule interacts with dipole moment of other
Stronger than dipole dipole