Non- Alcoholic Fatty Liver Disease Flashcards
1
Q
What is NAFLD?
A
A condition in which fat accumulates in the liver in people who drink little or no alcohoL
2
Q
What are the 3 entities of NADLF?
A
- Simple steatosis
- Non alcohol steatohepatitis
- Fibrosis and cirrhosis
3
Q
What are the risk factors of NAFLD?
A
- Diabetes
- Obesity
- Hypertriglyceridemia
- Hypertension
- Age
- Ethnicity
- Genetic factors
4
Q
What is the natural history of NAFLD?
A
Normal liver
10-35% Steatosis
12-40% NASH
15% Cirrhosis
5
Q
What is steatosis?
A
Increased fat in hepatocytes
6
Q
What is NASH?
A
Non alcohol steatohepatitis
7
Q
What is the NAFLD score?
A
High risk of fibrosis:
Age >45
Diabetes present
BMI>30
AST: ALT >1 (AST>ALT)
Platelet count <150
Albumin <34
8
Q
What is AST?
A
Aspartate aminotransferase- one of the 2 liver enzymes
9
Q
What is ALT?
A
Alanine aminotransferase- one of the 2 liver enzymes
10
Q
What is Fib-4 score?
A
Fib 4= Age x AST level
————————
Platelet count x square root of ALT
11
Q
What are the treatment options for NAFLD?
A
- Diet and weight reduction
- Exercise
- Insulin sensitizers
- Glucagon like peptide 1 (GLP-1)
- Vitamin E
- Weight reduction surgeries
