NMJ Disorders

Question 1

transient neonatal myasthenia

Answer 1

mothers c MG

present in first few hrs then resolves p 2-3 wks

diff feeding

gen weakness

respi prob, weak cry

facial weakness and ptosis

Question 2

congenital myasthenia

Answer 2

genetic disorder can present neonatal, childhood or adult

ptosis, ophtalmoparesis, facial weak, hypotonia

Question 3

autoimmune myasthenia

Answer 3

insidous

acute respi prob

ptosis, ophtalmoparesis, facial wekaness

swallong diff

weak trunk and limbs more proximal

tired or weak at end of day

Question 4

infantile botulism

Answer 4

bet 10 d to 6 mo and (+) clostridium botulinum toxin

acute hypotonia

dysphagia, weak cry

constipation

respi insuff

ptosis

weakness

Question 5

acquired botulism

Answer 5

poorly cooked pork or open wound then bacteria from soil

ptosis, diplopia, dilation

bulbar weakness

constipation