Cerebral Palsy Flashcards
what is cerebral palsy
nonprogressive but changing motor impairment syndromes
when does CP develop
in utero until 6 yo
basta developing brain
discuss little’s disease
spastic diplegia type
most common antenatal cause
prematurity
most common perinatal cause
asphyxia
most common cause overall
prematurity
low levels of iodine
diplegia
exposure to organic mercury
quadriplegia
intrauterine subdural hemorrhage
hemiplegia
discuss how infection causes CP
fetoplacental or uterine infection causes preterm labor and inc cytokines = PVL
chorioamniotis - most common assoc c CP
TORCHS - 5%
discuss how multiple gestation causes CP
at risk for preterm, growth restriction and low birth weight
twinning is the strongest risk factor bcs death = CP on surviving
discuss how pregnancy complications causes CP
thrombophilias - injury to placenta and clotting of fetal vessels
hemorrhage and preeclampsia - premature delivery
discuss how birth asphyxia causes CP
cord coiling. pelvic disproportion and poor contraction of uterus
meconium aspiration
discuss how prematurity causes CP
under 800g
APGAR of less than 3
discuss how Hyperbiliribinemia causes CP
G6PD can lead to CP
postnatal causes of CP
stroke, clotting prob, AVM
drowning
head trauma
meningitis/encephalitis
cardiopulmo arrest
how does magnesium sulfate treat CP
for preterm labor - inc seizure threshold in mothers c preeclampsia
can reduce risk of CP and protections
how does antibiotics treat CP
reduces infections = dec chorioamniotis
how does corticosteroids treat CP
inhibits cytokines = dec PVL
which pathologies is the premature brain susceptible to
IVH
PVL - related to CP
both affect corticospinal = CP
what is PVL
WM in the perieventricular region is underdeveloped or damaged
from ischemia or infection
what is IVH
bleeding into the ventricles of brain = prob in development
discuss BG lesions
high correlation c early jaundice
kernicterus - bilirubin encephalopathy
- dyskinetic CP
