Cerebral Palsy

Question 1

what is cerebral palsy

Answer 1

nonprogressive but changing motor impairment syndromes

Question 2

when does CP develop

Answer 2

in utero until 6 yo

basta developing brain

Question 3

discuss little’s disease

Answer 3

spastic diplegia type

Question 4

most common antenatal cause

Answer 4

prematurity

Question 5

most common perinatal cause

Answer 5

asphyxia

Question 6

most common cause overall

Answer 6

prematurity

Question 7

low levels of iodine

Answer 7

diplegia

Question 8

exposure to organic mercury

Answer 8

quadriplegia

Question 9

intrauterine subdural hemorrhage

Answer 9

hemiplegia

Question 10

discuss how infection causes CP

Answer 10

fetoplacental or uterine infection causes preterm labor and inc cytokines = PVL

chorioamniotis - most common assoc c CP

TORCHS - 5%

Question 11

discuss how multiple gestation causes CP

Answer 11

at risk for preterm, growth restriction and low birth weight

twinning is the strongest risk factor bcs death = CP on surviving

Question 12

discuss how pregnancy complications causes CP

Answer 12

thrombophilias - injury to placenta and clotting of fetal vessels

hemorrhage and preeclampsia - premature delivery

Question 13

discuss how birth asphyxia causes CP

Answer 13

cord coiling. pelvic disproportion and poor contraction of uterus

meconium aspiration

Question 14

discuss how prematurity causes CP

Answer 14

under 800g

APGAR of less than 3

Question 15

discuss how Hyperbiliribinemia causes CP

Answer 15

G6PD can lead to CP

Question 16

postnatal causes of CP

Answer 16

stroke, clotting prob, AVM

drowning

head trauma

meningitis/encephalitis

cardiopulmo arrest

Question 17

how does magnesium sulfate treat CP

Answer 17

for preterm labor - inc seizure threshold in mothers c preeclampsia

can reduce risk of CP and protections

Question 18

how does antibiotics treat CP

Answer 18

reduces infections = dec chorioamniotis

Question 19

how does corticosteroids treat CP

Answer 19

inhibits cytokines = dec PVL

Question 20

which pathologies is the premature brain susceptible to

Answer 20

IVH

PVL - related to CP

both affect corticospinal = CP

Question 21

what is PVL

Answer 21

WM in the perieventricular region is underdeveloped or damaged

from ischemia or infection

Question 22

what is IVH

Answer 22

bleeding into the ventricles of brain = prob in development

Question 23

discuss BG lesions

Answer 23

high correlation c early jaundice

kernicterus - bilirubin encephalopathy
- dyskinetic CP