Newborn Hyperbilirubinemia Flashcards
Causes of NB hyperbilirubinemia?
- hemolysis
- decreased serum albumin binding
- Impaired liver function
Condition resulting from a deposition of yellow pigmentation in the basal ganglia of the brain in NB?
Kernicterus (bilirubin > 25)
Therapy for hyperbilirubinemia?
- phototherapy
- hydration
- protect the eye
- observe for:
- dehydration, diarrhea, rashes
The NB presents with dimished Moro reflex, poor sucking, high-pitched cry, setting sun eyes, a sunken anterior fontanel and green stool, what do you suspect?
hyperbilirubinemia
How does phototherapy help tx hyperbilirubinemia in a NB?
speeds up conjugation of bilirubin
What is Iso-Immunization?
development of antibodies against antigens from the same species
What is the medication given to prevent Iso-immunization from Rh factor?
Rhogam
What is Erythroblastosis Fetalis?
when the fetus produces large amounts of immature erythrocytes to replace those lost due to anemia
What is hydrops fetalis?
- severe form of Erythroblastosis Fetalis
- fetus has marked anemia, cardiac decompensation, cardiomegaly, and hepatosplenomegaly
- tx is done in utero with a transfusion via the umbilical cord after 17 weeks of gestation
Why is a COOMBS test done?
- to determine presence of Rh/ABO serum antibodies
- Direct - tests cord blood
- Indirect - tests mom’s serum
Why is the Kleihauer-Betke test done?
- measures the amount of fetal hemoglobin transferred to mothers bloodstream
- to test for the need for RhoGam
When is RhoGam given?
- only if woman is Rh- and not sensitized
- Anterpartum at 28 weeks
- Within 72 of:
- significant 1st or 2nd timester bleeding
- abortion or miscarriage
- CVS or amniocentesis
- birth of Rh+ baby
How long do the effects of Rhogam last?
12 weeks
Baby presents with elbow ectended, hand rotated inward, no moros’ reflex and intact grasp in one arm. What do you suspect and how to treat?
- Erb Duchennes palsy
- immobility for 1st week, then passive ROM
What is the vector for toxoplasmosis?
cat feces (garden soil) and raw or undercooked beef or pork
How is an infection with toxoplasmosis dx in an NB?
elevated cord blood serum IgM
Group B Strep can lead to what in a newborn?o
sepsis, pneumonia, meningitis
How long is the NB observational period for GBS?
48 hrs after delivery
How is fetal alcohol syndrome diagnosed?
- facial characteristics
- growth delays
- CNS
- developmental delays
- mental retardation
- behavioral problems
- learning disabilities/hyperactivity
FAS facial features?
- microcephaly
- short palpebral fissures
- flat midface
- low nasal bridge
- epicanthal folds