Neurotransmission and Drugs Flashcards
Any molecule to binds to a receptor
Ligand
The reabsorption of a neurotransmitter by a neurotransmitter transporter in the presynaptic neuron
Reuptake
Determine the effect of a ligand
Postsynaptic receptors and channels
Most common neurotransmitter found throughout the brain
Glutamate
Is Glutamate inhibitory or excitatory?
Exitatory
Ionotropic receptor that allows for flow of multiple ions, causing depolarization
AMPA
Ionotropic receptor that contains magnesium. Requires relatively intense depolarization to open channels
NMDA
Second most common neurotransmitter in the brain, Most inhibitory neurotransmitter
GABA
Excitatory and Inhibitory neurotransmitter that activates muscles. Found in the brain and the PNS
Acetylcholine (ACh)
Synapses between motor neurons and muscle fiber
Neuromuscular junctions
Toxic chemical weapon that inhibits ACh, lethal
Sarin
Family of neurotransmitter that includes Epinephrine, Norepinephrine, and Dopamine
Catecholamines
Neurotransmitter that mobilizes brain and body for action
Norepinephrine
Autonomic nervous system responsible for activating fight or flight
Sympathetic Nervous System
brain stem nuclei that produces norepinephrine
Locus Coeruleus
Neurotransmitter responsible for movement, reward-seeking, and motivation
Dopamine
Neurotransmitter that affects happiness, sleep, and appetite
Serotonin (5-HT)
Brain stem nuclei that produces Serotonin
Raphe Nuclei
Family of neurotransmitter that includes Endorphins and Enkephalin
Opioids
neurotransmitter that can reverse neurotransmission by returning to the presynaptic side
Nitric Acid
Molecule that enhances function of synapse (enhance either EPSPs or IPSPs, depending on the synapse)
Agonist
Molecule that reduces function of synapse (reduce either EPSPs or IPSPs, depending on the synapse)
Antagonist
Agonist that stimulates the release of and/ or prolongs a neurotransmitter
Presynaptic Agonist
Agonist that activates receptors by mimicking a neurotransmitter
Postsynaptic Agonist
Antagonist that prevents the release of a neurotransmitter
Presynaptic Antagonist
Antagonist that blocks receptors
Postsynaptic Antagonist
Molecule that induces the opposite of a synapse’s function
Inverse Agonist