Neurotic disorders Flashcards
1
Q
What is neuroleptic malignant syndrome?
A
Toxic side effect of anti-psychotics
2
Q
Which drug is NMS associated most?
A
Haloperidol and clozapine
3
Q
What are the symptoms of NMS?
A
Hyperthermia, fluctuating level of consciousness (confusion),muscular rigidity and autonomic disturbance fatal.
4
Q
When does NMS most commonly occur?
A
most commonly in first 2 weeks
5
Q
What causes NMS?
A
Inc levels of serotonin, caused by over activation of 5-HT1 a and 2 receptors.
6
Q
What 5 receptors do anti-psychotics act on?
A
Dopamine, serotonin, alpha 1 adrenergic, muscarinic cholinergic and histamine.
