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Mechanism of Drug Action (Drugs) > Neuropharmacology (Drugs - General) > Flashcards

Neuropharmacology (Drugs - General) Flashcards

1
Q

What are the agonists of Glu AMPA receptor?

A
  1. Glu
  2. Kainic acid
  3. Domoic acid
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2
Q

What are competitive antagonists of AMPA receptors?

A
  1. NBQX
  2. CNQX
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3
Q

What are non-competitive antagonists of AMPA receptors?

A

2,3-Benzodiazepines

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4
Q

What are the agonists of NMDA receptors?

A
  1. Glu
  2. Glycine
  3. D-serine
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5
Q

What are the antagonists of NMDA receptors?

A
  1. APV (competitive with Glu)
  2. Kynurenic acid (competitive with glycine, non competitive with Glu)
  3. Open channel blockers
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6
Q

What are the NMDA open channel blockers?

A
  1. PCP
  2. MK801
  3. Memantine
  4. Ketamine
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7
Q

What are the clinical uses of memantine?

A

Alzheimer’s disease

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8
Q

What are the clinical uses of ketamine?

A
  • Dissociative anaesthesia
  • Also has antidepressant properties
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9
Q

What are the non-specific mGluR agonists?

A
  1. Glutamate
  2. ACPD
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10
Q

What are the specfic mGluR agonists?

A
  1. Group I: DHPG
  2. Group II: DCG-IV
  3. Group III: L-AP4
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11
Q

What are the mGluR antagonists?

A
  1. MCPG: Group I & II
  2. CPPG: Group III
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12
Q

What are examples of GABAA receptor agonists?

A
  1. GABA
  2. Muscimol
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13
Q

What are examples of GABAA antagonists?

A
  1. Bicuculline
  2. Picrotoxin
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14
Q

What are examples of barbiturates?

A
  1. Phenobarbital
  2. Thiopental
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15
Q

What are the PK properties of phenobarbital and its clinical uses?

A
  • Long action
  • Used as anxiolytic and anticonvulsant
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16
Q

What are the PK properties of thiopental and its clinical uses?

A
  • Fast acting
  • Used as anaesthetic
17
Q

What are examples of benzodiazepines?

A
  1. Cloazepam
  2. Diazepam
  3. Lorazepam
18
Q

What is an example of a benzodiazepine antagonist?

A

Flumazenil

19
Q

What is the mechanism of action of Z-drugs?

A

Binds to benzodiazepine binding sites on GABAA receptors, preferentially the α2 subunit. Acts as an agonist of GABAA receptors to produce anxiolytic effect.

20
Q

What are examples of Z-drugs?

A
  1. Zolpidem
  2. Zopiclone
  3. Zaleplon
21
Q

What are the benefits of Z-drugs over benzodiazepines?

A

Less addictive

22
Q

What are examples of GABAB receptor agonists?

A

Baclofen

23
Q

When are the clinical uses of GABAB agonists?

A

Sedative

24
Q

What are examples of GABAB receptor antagonists?

A
  1. Saclofen
  2. Phaclofen
25
Q

What are the clinical uses of GABAB antagonists?

A

Prevents seizures (antiepileptic)

26
Q

What are the uses of drugs that modulate 5-HT transmission?

A
  1. Antidepressants (e.g. SSRIs)
  2. Antipsychotics
  3. Antiemetics (5-HT3 antagonists)
  4. Migraine (5-HT1D agonist)
27
Q

What are the drugs that inhibit dopamine vesicular transport?

A

Reserpine

Mechanism of Drug Action (Drugs) (26 decks)

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