Angina (Drugs) Flashcards
1
Q
What are the types of anti-anginal drugs?
A
- Organic nitrates
- β blockers
- Ca2+ channel blockers
- If blockers
- Late Na+ current blockers
2
Q
What are examples of organic nitrates?
A
- Glyceryl trinitrate
- Isosorbide dinitrate (metabolised to active isosorbide mononitrate in liver)
- Amyl nitrate
3
Q
What are examples of If blockers?
A
Ivabradine (HCN antagonist)
4
Q
What is the most commonly used class of Ca2+ channel blockers used to treat angina?
A
Dihydropyridines
5
Q
What is an example of a late Na+ current inhibitor?
A
Ranolazine
6
Q
What are the roles of nicorandil in treatment of angina?
A
- KATP opener and mimics the effects of ischaemic pre-conditioning
- NO donor and may help in pre-conditioning as part of NO-dependent pathway
- Opens vascular KATP channels and decreases afterload on heart
7
Q
What is the role of adenosine in treating angina?
A
Adenosine binds to A1 receptors that may contribute to ischaemic pre-conditioning
8
Q
What are the surgical interventions used to treat angina?
A
- Coronary artery bypass grafting
- Percutaneous coronary intervention
9
Q
What drugs are used to prevent neointimal proliferation following stent insertion in drug-eluting stents?
A
- Sirolimus
- Paclitaxel
