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Mechanism of Drug Action (Drugs) > Drug Interactions with Receptors and Ion Channels (Drugs) > Flashcards

Drug Interactions with Receptors and Ion Channels (Drugs) Flashcards

1
Q

What are the molecules that disrupt G-protein cycle?

A
  1. Cholera toxin (CTX): Inhibits GTPase activity of αs, causing chronic activation of pathway.
  2. Pertussis toxin (PTX): ADP-ribosylates αi and inhibits stimulation, causing ‘whooping cough’.
  3. AlF4-: Mimics γ-phosphate and causes chronic activation of G-proteins. It is used as an insecticide.
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2
Q

What is the role of lithium in PLC pathway?

A

Inhibits inositol-1 phosphotase and thus inositol recycling in the brain.

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3
Q

What are examples of glucocorticoid agonists/antagonists?

A

Agonist: Hydrocortisone

Antagonist: Mifepristone

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4
Q

What are examples of mineralocorticoid agonists/antagonists?

A

Agonist: Fludrocortisone

Antagonist: Spironolactone

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5
Q

What are examples of oestrogen agonists/antagonists?

A

Agonist: Ethinylestradiol

Antagonist: Tamoxifen

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6
Q

What are examples of progestagen agonists/antagonists?

A

Agonist: Norethisterone

Antagonist: Danazol

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7
Q

What are examples of androgen agonists/antagonists?

A

Agonist: Stanozolol

Antagonist: Flutamide

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8
Q

What are examples of use-dependent local anaesthetics?

A
  • Procaine
  • Lidocaine
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9
Q

What is an example of a use-independent local anaesthetic?

A

Benzocaine

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10
Q

What are examples of quaternary local anaesthetics?

A

QX 314

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11
Q

What are examples of Nav activators?

A
  • Batrachotoxin
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12
Q

What are examples of dihydropyridines?

A

Agonist: Bay K 8644

Antagonist: Nifedipine, amlodipine

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13
Q

What are examples of phenylakylamines?

A
  • Verapamil
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14
Q

What are examples of benzothiazepines?

A
  • Diltiazem
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15
Q

What are examples of sulphonylurias?

A
  • Tolbutamide
  • Glibenclamide
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16
Q

What are the irreversible Nav inhibitors?

A
  • Tetrodotoxin (TTX)
  • Saxitoxin (STX)
17
Q

What is an activator of Nav?

A
  • Batrachotoxin
  • Aconitine
  • Veratridine
18
Q

What feature of irreversible Nav inhibitors allow them to function?

A

Guanidinium group

Mechanism of Drug Action (Drugs) (26 decks)

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