Neuropath of CNS Infections I Flashcards
Herpes Viruses uses ______ transport to infect neurons
retrograde
Neutrophils are associated with _____ inflammation usually caused by _____
acute; bacteria
Lymphocytes are usually associated with ______ infections
viral
Microglial nodules are associated with _____ _____
viral encephalitis
Microglial cells are a type of ____ which are resident to the CNS
macrophage
Pachymeningitis is inflammation of the ____
Dura
Leptomeningitis is inflammation of the ____
Pia and Arachnoid
Encephalitis is a term used for ______ inflammation of the brain parenchyma
chronic
Cerebritis refers to _____ inflammation
acute
Myelitis is inflammation of the
spinal cord
Poliomyelitis is inflammation of the
spinal cord grey matter
Epidural abscesses occur most frequently in the
spine
The most common location for a bacterial infection is the
subarachnoid space
The most common way for a patient to get a bacterial abscess is ________ spread
hematogenous
The most common source of bacterial emboli is ________
endocarditis
The most common abscess forming bacteria are
Staph Aureus and Strep
The fibrous scar around abscesses in the brain result from
vessels from the leptomeninges providing fibroblasts
Mycobacteria and neurosyphilis cause a ____ infection of the brain
chronic
Tuberculous meningitis occurs in the ____ aspect of the brain and can cause _____ ______ ______
basal; cranial nerve palsy
Tuberculous meningitis can form tuberculomas, which are
granulomas with a necrotic core surrounded by multinucleated giant cells
CNS involvement of syphilis occurs in the _____ stage
tertiary
Meningovascular Neurosyphilis form lesions called _____. They also have a _____ infiltrate made up of ______
gummas; perivascular; lymphocytes
The two major symptoms of neurosyphilis are
Tabes Dorsalis and Paretic Neurosyphilis
Organisms can only be seen in which of the two major neurosyphilitic syndromes?
Paretic Neurosyphilis
Paretic Neurosyphilis has inflammatory lesions which cause _____ damage
parenchymal
Lyme disease is a cause of isolated
Facial nerve palsy
Lyme disease causes what type of meningitis?
Aseptic lymphocytic meningitis
____ causes 80% of aseptic viral meningitis
Enterovirus
____ are seasonal RNA viruses which are transmitted by
Arboviruses; arthropods
Acute viral encephalitis present with both ____ infiltrates and _____ nodules
perivascular; microglial
____ is the destruction of neurons by phagocytes seen in ___ ____ _____
Neuronophagia; acute viral encephalitis
HSV1 has a predilection to cause hemorrhagic necrosis in the ______ lobe in a _____ pattern
temporal; bilateral
CMV encephalitis occurs in which two primary ways?
Intrauterine infection (congential CMV) and immunosuppression
_____ can cause encephalitis in immunosuppressed patients
Varicella Zoster
Rabies infections start in _____ muscle then get to the CNS via ____
skeletal; retrograde axonal transport
What is the pathological hallmark of rabies?
Negri Bodies
Poliomyelitis is restricted to the
grey matter of the spinal cord
Fungi can cause _____ lesions
granulomatous
Fungi have a predilection for ______, and can cause _____ and ______
vessels; infarcts; hemorrhage
Patients with neutropenia are at increased risk of infection by which two fungi?
Aspergillus and Candida
Zygomycosis often infect patients who are in ____ and cause
DKA; rhinocerebral disease
Epidemic outbreaks of meningitis are most associated with what bacteria?
Neisseria Meningitidis
Most common CNS infection
Bacterial Meningitis
What is the second most common CNS infection and when do they occur in life?
Bacterial abscess in 2nd or 3rd decade
Due to the influx of neutrophils, bacterial infections of the CNS have ______ infections
purulent
Initially, abscesses are filled with ____. Then after 10 days, a _______ capsule forms around the necrosis.
neutrophils; fibrotic
