Neuropath of CNS Infections I

Question 1

Herpes Viruses uses ______ transport to infect neurons

Answer 1

retrograde

Question 2

Neutrophils are associated with _____ inflammation usually caused by _____

Answer 2

acute; bacteria

Question 3

Lymphocytes are usually associated with ______ infections

Answer 3

viral

Question 4

Microglial nodules are associated with _____ _____

Answer 4

viral encephalitis

Question 5

Microglial cells are a type of ____ which are resident to the CNS

Answer 5

macrophage

Question 6

Pachymeningitis is inflammation of the ____

Answer 6

Dura

Question 7

Leptomeningitis is inflammation of the ____

Answer 7

Pia and Arachnoid

Question 8

Encephalitis is a term used for ______ inflammation of the brain parenchyma

Answer 8

chronic

Question 9

Cerebritis refers to _____ inflammation

Answer 9

acute

Question 10

Myelitis is inflammation of the

Answer 10

spinal cord

Question 11

Poliomyelitis is inflammation of the

Answer 11

spinal cord grey matter

Question 12

Epidural abscesses occur most frequently in the

Answer 12

spine

Question 13

The most common location for a bacterial infection is the

Answer 13

subarachnoid space

Question 14

The most common way for a patient to get a bacterial abscess is ________ spread

Answer 14

hematogenous

Question 15

The most common source of bacterial emboli is ________

Answer 15

endocarditis

Question 16

The most common abscess forming bacteria are

Answer 16

Staph Aureus and Strep

Question 17

The fibrous scar around abscesses in the brain result from

Answer 17

vessels from the leptomeninges providing fibroblasts

Question 18

Mycobacteria and neurosyphilis cause a ____ infection of the brain

Answer 18

chronic

Question 19

Tuberculous meningitis occurs in the ____ aspect of the brain and can cause _____ ______ ______

Answer 19

basal; cranial nerve palsy

Question 20

Tuberculous meningitis can form tuberculomas, which are

Answer 20

granulomas with a necrotic core surrounded by multinucleated giant cells

Question 21

CNS involvement of syphilis occurs in the _____ stage

Answer 21

tertiary

Question 22

Meningovascular Neurosyphilis form lesions called _____. They also have a _____ infiltrate made up of ______

Answer 22

gummas; perivascular; lymphocytes

Question 23

The two major symptoms of neurosyphilis are

Answer 23

Tabes Dorsalis and Paretic Neurosyphilis

Question 24

Organisms can only be seen in which of the two major neurosyphilitic syndromes?

Answer 24

Paretic Neurosyphilis

Question 25

Paretic Neurosyphilis has inflammatory lesions which cause _____ damage

Answer 25

parenchymal

Question 26

Lyme disease is a cause of isolated

Answer 26

Facial nerve palsy

Question 27

Lyme disease causes what type of meningitis?

Answer 27

Aseptic lymphocytic meningitis

Question 28

____ causes 80% of aseptic viral meningitis

Answer 28

Enterovirus

Question 29

____ are seasonal RNA viruses which are transmitted by

Answer 29

Arboviruses; arthropods

Question 30

Acute viral encephalitis present with both ____ infiltrates and _____ nodules

Answer 30

perivascular; microglial

Question 31

____ is the destruction of neurons by phagocytes seen in ___ ____ _____

Answer 31

Neuronophagia; acute viral encephalitis

Question 32

HSV1 has a predilection to cause hemorrhagic necrosis in the ______ lobe in a _____ pattern

Answer 32

temporal; bilateral

Question 33

CMV encephalitis occurs in which two primary ways?

Answer 33

Intrauterine infection (congential CMV) and immunosuppression

Question 34

_____ can cause encephalitis in immunosuppressed patients

Answer 34

Varicella Zoster

Question 35

Rabies infections start in _____ muscle then get to the CNS via ____

Answer 35

skeletal; retrograde axonal transport

Question 36

What is the pathological hallmark of rabies?

Answer 36

Negri Bodies

Question 37

Poliomyelitis is restricted to the

Answer 37

grey matter of the spinal cord

Question 38

Fungi can cause _____ lesions

Answer 38

granulomatous

Question 39

Fungi have a predilection for ______, and can cause _____ and ______

Answer 39

vessels; infarcts; hemorrhage

Question 40

Patients with neutropenia are at increased risk of infection by which two fungi?

Answer 40

Aspergillus and Candida

Question 41

Zygomycosis often infect patients who are in ____ and cause

Answer 41

DKA; rhinocerebral disease

Question 42

Epidemic outbreaks of meningitis are most associated with what bacteria?

Answer 42

Neisseria Meningitidis

Question 43

Most common CNS infection

Answer 43

Bacterial Meningitis

Question 44

What is the second most common CNS infection and when do they occur in life?

Answer 44

Bacterial abscess in 2nd or 3rd decade

Question 45

Due to the influx of neutrophils, bacterial infections of the CNS have ______ infections

Answer 45

purulent

Question 46

Initially, abscesses are filled with ____. Then after 10 days, a _______ capsule forms around the necrosis.

Answer 46

neutrophils; fibrotic