Neuromuscular Conditions (CP, Spina bifida and muscular dystrophy) Flashcards

1
Q

Prenatal causes of cerebral palsy

A
Placental insufficiency
Toxaemia
Smoking
Alcohol
Drugs
Infection
ToRCH
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2
Q

Perinatal causes of CP

A
pre-maturity
Anoxic injuries
Infection
Kernicterus
Eythroblastosis fetalis (HDN)
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3
Q

Post natal causes of CP

A

Infection - CMV, rubella

Head trauma

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4
Q

What is cerebral palsy

A

Permanent and non-progressive motor disorder due to brain damage before birth or during first 2 years of life
Lesion is static but clinical picture is not

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5
Q

What are the physiological classifications of CP

A

Spastic (pyramidal system, motor cortex)
Athetoid (extrapyramidal system, basal ganglia)
Ataxia (cerebellum and brainstem)
Rigid (basal ganglia and motor cortex)
Hemiballistic
Mixed (combination of spasticity and athetosis)

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6
Q

What are the anatomical classifications?

A

Monoplegia
Hemiplegia
Diplegia
Quadriplegia or total body involvement

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7
Q

What is needed for diagnosis of CP

A

Spasticity, lack of voluntary control, weakness, poor co-ordination, sensory impairment
Persistence of 2 or more primitive reflexes usually means child will be non ambulatory

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8
Q

Management of CP

A

Motor, sensory, cognitive problems, epilepsy, feeding difficulties, behavioural problems

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9
Q

What are the prerequisites of normal gait?

A
Stability in stance
Clearance in swing
Preposition of foot
Adequate step length
Energy conservation
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10
Q

What is antalgic gate?

A

Reduced stance phase

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11
Q

What is trendelenburg gate?

A

Pelvis drops on opposite side to foot standing on

Caused by weakness of abductor muscles of lower limb and gluteus medius and minimus

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12
Q

What are concentric muscle actions

A

Shortening
Power generation
Acceleration

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13
Q

What are eccentric muscle actions

A

Controlled lengthening
Power abrorption
deceleration

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14
Q

What is GMFCS

A

Grading on CP patients ability to walk

Levels 1-5 with 5 most severe

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15
Q

What is spina bifida

A

Failure to close neural tube

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16
Q

What are the types of spina bifida

A

Occulta (benign)
Meningocele (rare, cyst removed, usually neurologically intact)
Myelomeningocele (nerve roots in cyst or exposed
Encephalocele
Anencephaly

17
Q

Complications of Myelomeningocele

A
Hydrocephaly 
Chiari II malform
Tethered cord
Urinary tract problems
Locomotor limitation
Latex allergy (3/4)
Learning disability (1/5)
18
Q

What is protective for spina bifida

A

Folic acid

19
Q

What is muscular dystrophy

A

Progressive muscle weakness

20
Q

\What are some types of muscular dystrophy

A
Facioscapulohumeral
Duchenne
Becker's
Limb girdle
Myotonic
Oculo-pharyngeal
Emery Dreifus
21
Q

What is used in diagnosis of muscular dystrophy?

A

Muscle biopsy
DNA
Blood enzymes (creatinine kinase) and EMG

22
Q

What is creatinine kinase released by

A

Damaged muscles

23
Q

What are features of duchenne muscular dystrophy

A
X-linked recessive
Failure to make dystrophin
Proximal weak 4yrs 
'psuedohypertrophy' (muscles become swollen with fat)
Wheelchair by 12yrs
Most get scoliosis 
Surgery indicated
24
Q

Features of becker muscular dystrophy

A

?Same gene as duchenne but there is limited but poor dystrophin
Milder than duchenne
Later onset
Wheelchair by 30years

25
Q

What sign is pathonomic for muscular dystrophy?

A

Gower Maneuver