Multi-system Autoimmune Disease

Question 1

Who gets SLE

Answer 1

F>M 9:1
Onset before 55 years
Afrocarribean > Asian > Caucasian

Question 2

Classification of SLE

Answer 2

Any 4 of
Malar rash, Discoid rash, Photosensitivity, Oral ulcers, Arthritis (>2), Serositis, Renal, Neurological, ANA, Haematological (low wcc and platelets), Immunological (anti-ds DNA, lupus anticoagulant)

Question 3

SLE investigations

Answer 3

Increased ESR, CRP same
ANTI dsDNA
Increased RF, IgG/M, CT brain, MRI white matter

Question 4

Treatment for SLE

Answer 4

NSAIDs, CCS, Isoniazid, methyldopa, hydralazine

Question 5

What is scleroderma

Answer 5

Heterogenous group linked by presence of thickened sclerotic skin lesions
Onset 30-50 years
F > M 3:1

Question 6

Types of scleroderma

Answer 6

Limited - can cause pulmonary hypertension
Diffused - can cause pulmonary fibrosis, renal crisis, small bowel bacterial overgrowth
Morphea

Question 7

Who does Sjogrens Syndrome affect

Answer 7

F>M

Onset 40-50 years

Question 8

Clinical features of Sjogren’s Syndrome

Answer 8

Dry eyes and mouth
Parotid gland enlargement
1/3 have systemic upset

Question 9

Complications of Sjogren’s syndrome

Answer 9

Lymphoma
Neuropathy
Purpura
Renal tubular acidosis
Interstitial lung disease