Neurology Flashcards

1
Q

what is a febrile convulsion

A

generalised tonic-clonic seizure occurring in child with fever

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2
Q

what is a breath holding attack

A

child is upset/crying/worked up and stops breathing, becomes cyanotic and loses consciousness
- recover within 1 minute

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3
Q

what is a reflex anoxic seizure

A

occurs when child is startled

  • vagnus nerve sends signals to heart for it to stop beating
  • child goes pale, collapses and may have some seizure like muscle twitching
  • heart returns to normal within 30s and child regains consciousness
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4
Q

what are the types of epileptic seizures

A
focal seizures
absence seizures
atonic seizures
myoclonic seizures 
tonic seizures
clinic seizures
tonic-clonic seizures
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5
Q

where to focal seizures occur

A

temporal lobe

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6
Q

difference between

  • simple focal seizure
  • complex focal seizure
A
simple = without loss of consciousness
complex = with loss of consciousness
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7
Q

symptoms of focal seizure

A

hallucinations
deja vu
memory flashbacks
repetitive movements on autopilot

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8
Q

Tx of focal seizures

- 1st line

A

1st line: carbamazepine / lamotrigine

2nd line: sodium valproate

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9
Q

how does an absence seizure present

A

child becomes blank, stares into space, unresponsive then upruptly returns back to normal

  • typically lasts 10-20 s
  • majority stop having seizures as they grow up
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10
Q

tx of absence seizures

A

1st line: sodium valproate or ethosuximide

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11
Q

how does a atonic seizure present

A

sudden loss of muscle tone causing collapse - ‘drop attack’

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12
Q

tx of atonic seizures

A

1st line: sodium valproate

2nd line: lamotrigine

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13
Q

presentation of a myoclonic seizure

A

sudden brief jerks in arms + legs

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14
Q

what is juvenile myoclonic epilepsy

A

early morning myoclonic seizures

daytime absences

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15
Q

tx of myoclonic seizures

A

sodium valproate

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16
Q

presentation of a tonic seizure

A

stiffening of muscles in back / arms / legs

17
Q

presentation of a clonic seizure

A

rhythmic jerking movements

18
Q

presentation of a tonic clonic seizure

A

‘grand mal’ seizure

  • loss of consciousness
  • muscle tensing + rhythmic jerking movements
  • post ictal period
  • may experience tongue biting / incontinence
19
Q

tx of tonic-clonic seizures

A

1st line: sodium valproate

2nd line: lamotrigine

20
Q

what is sodium valproate’s mechanism of action?

what are the side effects?

A

increases GABA activity

  • teratogenic
  • liver damage / hepatitis
  • hair loss
  • temor
21
Q

what is lamotrigine’s mechanism of action?

what are the side effects?

A

blocks sodium channels

- Steven Johnston syndrome

22
Q

what channels does carbamazepine act on?

what are the side effects of carbamazepine?

A

sodium channels

  • agranulocytosis
  • aplastic anaemia
  • induces p450 system
23
Q

what is hydrocephalus

A

increased CSF within brain/spinal cord
either due to
- overproduction
- problem with draining / absorption

24
Q

signs of hydrocephalus in an infant

A

enlarging head size
bulging fontanelles
poor feeding / vomiting
papilloedema

25
Q

most common congenital cause of hydrocephalus

A

aqueductal stenosis leading to decreased drainage

26
Q

management of hydrocephalus

A

Ventriculoperitoneal shunt

27
Q

what is cerebral palsy

A

permanent neurological problems resulting from hypoxic damage to the brain around the time of birth

28
Q

what is an infantile spasm

A

repeated flexion of head, arms + trunk followed by extension of arms (‘Salaam attack’)

  • poor prognosis
  • progressive mental handicap
29
Q

EEG changes in an infantile spasm

A

hypsarrhythmia

30
Q

most common cause of headache in children

A

migraine