Neurology Flashcards
What is Lhermitte’s sign and what is it associated with ?
Electrical shock signal that shoots down the spine during neck flexion. Associated with MS
What are the three cortical defects (types ) of fronto-temporal dementia
1) Frontal - (associated with Picks disease) Personality disorders
2) Primary Progressive - loose the ability to use language to speak, read, write, and understand what others are saying.
3) Semantic - loose vocabulary over time
What is parinaud syndrome and what is it associated with ?
inability to gaze upwards due to a pineocytoma - pineal gland tumour. The syndrome occurs when there is compression of the superior colliculus.
Where do JPA astrocytomas occur and what syndrome is it associated with> (Juvenille pilocytic astrocytoma )
Posterior fossa - midline cerebellum when not associated with NF1
. Associated with NF1- most common is optic nerves
Defining feature is increased diffusion ( so bright on ADC)
What grade 1 astrocytome is found at the foramen of monro and which patients develop them ?
Subependymal giant cell astrocytoma.
Tuberous sclerosis
What are the characteristic features of a pleomoprhic xanthoastrocytoma ?
Cystic lesions with part solid component which enhances post contrast. Slow growing with remodelling of the overlying skull
Enhancing dural tail
Where are astrocytomas IDH-mutant located ?
2/3 are supratentorial
Frontal lobe > temporal > parietal > occipital
Peripherally, they are cystic lesions which are
Hyperintense on T2/ Hypointense on FLAIR. = T2/FLair mismatch
They do not restrict diffusion
What doe oligodendric cells do?
Myelination of the neurones
What WHO grading are Oligodendroglial Tumours?
WHO 2/3 .
Higher grade is decided by histology - showing increased mitotic activity, endothelial proliferation and necrosis
Where are Oligodendroglial Tumours usually found?
Frontal and peripheral. 90% have calcification.
Where are choroid plexus tumours mots commonly found in children?
The lateral ventricles
Adults - 4th ventricles
Where are Dysembryoplastic neuroepithelial tumours usually found and what do they commonly present with?
Multicystic lesions usually within the temporal lobe - therefore presenting with epilepsy
What are the most common locations for a ICH in bleeds caused by hypertension
Basal ganglia, cerebellum, thalamus and pons
What are the main causes of masses within the posterior cranial fossa in adults
- Cerebella metastasis - lung/melanoma/breast/thyroid
- Haemangioblastoma
- Lymphoma
What disease is associated with haemangioblastoma?
Von Hippel lindau disease or sporadic
What is the classic location of CADISIL
Anterior temporal lobe and external capsule
What is amyloid angiopathy
Accumulation of amyloid plaques within the small and medium vessels of the brain.
What disease is the sign, ‘puff of smoke’ associated with ?
Moyamoya disease. It is caused by the neo-vascularlisation resulting in the formation of small, abnormal vessels
What is moyamoya disease ?
Progressive narrowing of the distal portion of the ICA and circle of Willis with secondary collaterasliastion .
Moyamoa - is a puff of smoke due to collaterisation
What is clocc ? Is it a problem
Cytotoxic lesions of the corpus callosum , it is a benign condition
What condition is spinal ependymomas associated with ?
NF2
Where in the spinal cord are ependymomas located ?
Centrally within the spinal cord, causing expansion of the cord
Do ependymomas enhance ?
Yes they have heterogenous enhancement
What is the most common intramedullary tumour in children ?
Astrocytoma
What are astrocytomas associated with ?
NF1
What WHO grading is a spinal epdenymoma ?
WHO grad 2
What is the WHO grading for an intramedullary astrocytoma ?
WHO Grade 1/2
Which cancers most commonly metastases to the intramedullary spine ?
Lung and then breast
What condition should you think of in a patient with multiple hemangioblastomas ?
Von Hippel-Lindau syndrome
What is diastomytemylia , what is it associated with ?
The cord is split.
Desmoid cysts
what is communicating hydrocephalus and what causes it
increase in ventricles due to more csf volume - but no obstructing lesion.
It is caused by a destruction in CSF absorption by the arachnoid granulations, such as subarachoidnoid haemorrhage,meningitis or leptomeningeal metastasis
what is the classic triad of normal pressure hydrocephalus ?
ataxia, incontinence and dementia
what is cytotoxic oedema caused by
damaged sodium - potassium ATPase ion pumps which is due to acute ischameia
on imaging what does cytotoxic oedema look like ?
affects both grey-white matter
restricted diffusion due to the cells swelling
what is affected in vasogenic oedema
the blood Brain barrier is effected .
this causes fluid to go from the intracellular space to the extracellular space
there is increased grey-white matter differentiation
high t2/flair with facilitated diffusion
what is affected in vasogenic oedema
the blood Brain barrier is effected .
this causes fluid to go from the intracellular space to the extracellular space
there is increased grey-white matter differentiation
what does ionic oedema look like
this is associated with cytotoxic oedema and it results in fluid going from the blood to the extracellular space (do to the osmotic changes that occur with the cytotoxic oedema). there I therefore more fluid within the extracellular space which causes a high T2/Flair signal
what causes vasogenic oedema
brain tumours and abscesses
what is transependymal oedema
due to high intraventricular pressure
causes CSF to move from the ventricle into the extracellular space
usually due to obstructive hydrocephalus
causes high flair signal around the lateral ventricles
which artery might be compressed in subfalcine herniation and what is the clinical manifestation of this
anterior cerebral artery = the pericallosal artery
manifesting as contralateral leg weakess
what are the two types of transtentorial herniation?
central - where the basal ganglia and thalami are pushed down
lateral (uncal) - where the medial portion of the temporal lobe Is displaced
what affect can transtentorial herniation have ?
1) compression of the oculomotor nerve - causing pupillary dilatation
2) compression of the PCA - causing medial temporal/occipital lobe infarction
3) shearing of the perforating arteries from the basilar causing small haemorrhages
on Brain MRI what is T1 hyperintense
fat
melanin
proteinaceous material
methemoglobin
minerals - gad
what is T2 hypointense
most stages of blood - deoxyhaemaglobin, haemosiderin
calcification
fibrous tissue
highly cellular tumours - lymphoma and medulloblastoma
desiccated secretions into the paranasal sinuses
where does hypertensive microangiopahty affect
basal ganglia, thalami, cerebellum and pons
where does cerebral amyloid angiopathy affect
lobar in the cortico-subcortical sites , spares the deep structures
in MR spectroscopy what happens with Choline
marker of cell turnover and increases with most abnormalities
in MR spectroscopy what happens with NAA
marker of neuronal viability and decreases with most abnormalities
which way should hunters angle be pointing in normal Brian
normally the angle should be pointed upwards. as the Choline < Creating< NAA in a normal person.
In brain disease the angle point downwards
what might high choline levels distinguish
tumour vs edema
radiation induced cnecrosis
what might the prescence of 2-HG on MR Spectroscopy reveal
IDH - mutant status in gliomas
in MR spectroscopy, what are prominent lipid/lactate peaks associated with ?
high grade gliomas and lymphoma
what is very high on MR spectroscopy in Canavan disease >
NAA
this is a autosomal recessive condition where there is a deficiency in the n-acetylasparacylase which is important in myeline synthesis. this results in Increased NAA levels.
which CNS regions do no have a BBB
choroid plexus
pituitary and pineal glands
tuber cinereum - circadium rhythm in the inferior hypothalamus
area postream - controls vomiting and in the inferior aspect of the forth ventricle
which areas are typically affected in herpes encephalitis ?
medial temporal lobes and cingulate gyrus will show gyral enhancement with restricted diffusion
what are the key imaging features of a cerebral abscess
reduced diffusivity
hypointense rim on T2 weighted images
in MR, what is dural enhancement a sign of
dural edema due to a pathology
to see enhancement there must be both water and gad present. however the dural layer doesn’t usually have water. so only pathologies with water will show dural enhancement
which pathologies demonstrate dural enhancement ?
intracranial hypotension
post operatively
post lumbar puncture
meningeal neoplasm - meningioma
what does the leptomeninges include?
the Pia and arachnoid
what is the primary cause of leptomeningeal enhancement >
meningitis
which metastatic cancers cause leptomengieal enhancement
lymphoma and breast cancer
what does infarction of the artery of perchon result in
bilateral thamali infarction - as one artery supplies both
what does the recurrent artery of heubner supply?
the head of the caudate lobe and the anterior limb of the internal capsule
what’s the most common complication of a subarachnoid haemorrhage
vasospasm
what is the gold standard for diagnosisng vasospasm
DSA
what is the treatment of vaspasms.
the 3 Hs
hypertension
hypervolaemia
hemodilution
what drug is given to prevent vasospasm
oral nimodipin