Breast and Gynae and obstectrics Flashcards
what is basal-type breast carcinoma ?
triple negative phenotype (-HER2, -ER, -PR)
what do milk of calcium calcifications represent ?
free floating calcium in tiny benign cysts
what type of calcification is typical for fibroadenoma ?
popcorn like calcifications
what is an oil cyst ?
where an area of fat necrosis gets walled off by fibrous tissue.
usually have egg shell calcification
where do most breast cancers present ?
50% present in the upper outer quadrant
following breast cancer treatment what is the mammography follow up regime ?
if < 50, have yearly mammograms until 50 - and then go onto the normal breast screening program
If >50 have yearly mammogram for 5 years, and then go onto normal breast screening programme
At what week gestation should you see a gestational sac ?
5 weeks
At what week gestation should you see a gestational sac ?
5 weeks
How many weeks pregnant should you see a yolk sac ?
5.5 weeks
How many weeks should you see an embryo ?
6 weeks
If the CRL >7mm and there’s no heart beat , what does that indicate ?
A failed pregnancy
Where do most ectopic pregnancies occur ?
The ampulla
What is a heterotrophic pregnancy
IUP and Ectopic
What are the 3 forms of gestational trophoblastic disease ?
Complete hydtatidform mole
Invasive mole
Choriocarcinoma
What is a complete hydatidiform mole ?
Doesn’t contain any fetal parts ?
Why do complete hydatidiform moles occur ?
loss of the eggs DNA prior to fertilzation by the sperm and usually 46 Karyotype
What is the classic US appearance of a molar disease ?
Enlarged uterus, Multicystic bunch of grapes
In a molar pregnancy, what often occurs in the ovaries ?
Theca lutein cysts due to the elevated HCG ?
What is the treatment of a molar pregnancy ?
Endometrial suction curettage and 6 monthly follow up of HCG
What causes a partial hydatitform mole. ?
Triploid pregnancy XXX or XXY is caused by 2 sperm fertilising the same egg
What is chorionicity
Number of placentas
What is amnionicity
The number of aminos
What do monochorionic twins have ?
The same placenta
What do monoamniotic twins have ?
A single amniotic sac and therefore share a placenta
What is zygosity
Number of fertilised eggs
What does the twin peak sign indicate ?
Dichorionic/diamniotic twins
What does a T -shape configuration of the placenta and insertion of the intertwin membrane indicate
Monochorionic / diamniotic twins
What is diagnostic of mono/mono twins ?
Intertwined cords
What are conjoined twins caused by ?
Late >13 days incomplete division of the embryo
What are the Ultrasound findings of twin-twin transfusion syndrome ?
Single shared placenta
Disproportionate fetal sizes with ? 25% discrepancy
Disproportionate amniotic fluid with small twin having oligohydramnios
When is nuchal translucency measured ?
At 11-14 weeks or CRL 45-85mm
What thickness of nuchal translucency warrants further investigation ?
3mm
When could a omphalocele or gastroschisis be diagnosed and why ?
After 13 weeks, as normal midgut herniation occurs in the first trimester and is usually complete by 13 weeks
What is the most sensitive and specific ultrasound finding of Down’s syndrome
Thickened nuchal fold
What is an abnormal measurement for nuchal fold ?
> 6mm is a major marker for trisomy 21
What does cervical funnelling increase peoples risk of ?
Pre-term labour
Before 24 weeks, what is the treatment of cervical shortening ?
Cervical cerclage due to increased risk of pre-term labour
What does a single umbilical artery increase the risk of ?
Trisomy 13 and 18
What is velamentous insertion of the umbilical cord ?
Where the cord inserts outside the margin of the placenta, into the free membranes
What is vasa Previa?
Where the fetal placental vessels go across the internal cervical os
What is oligohydramnios most commonly associated with ?
IUGR