Neuroimaging of Clinical Symptoms

Question 1

what are clinical symptoms? intermediate phenotypes or phenotypes?

Answer 1

phenotypes

Question 2

architecture of task: in terms of how info flows through the circuit in your brain

Answer 2

EX: with a visual task

• start with primary visual cortex
• next goes to superior parietal cortex + inferior temporal region because there are 2 classes with a visual task

Question 3

what two classes are involved with a visual task?

Answer 3

1. object recognition - which happens in the inferior temporal region
2. spatial recognition - which happens in the superior parietal cortex

Question 4

in an imaging study or with any behavior experiment you need to know

Answer 4

what your task is giving you access to in the brain

Question 5

fMRI studies of learning dynamics in schizophrenia

Answer 5

uses tasks and info about how that task is implemented to study neuronal architecture in schizophrenia:

• frontal striatal attention: dopamine
• working memory: maintain info temporarily (narrowly described task to study in a region of the brain)
• motor system: motor control

Question 6

you can target a large number of domains as long as you know:

Answer 6

• rational for doing it
• what it causes (should cause)
• the domains it effects