Neurocognitive Disorders Flashcards

1
Q

Delirium

A

Disturbance in attention and awareness
- acute onset (h-d)
- change in baseline fluctuating with lucidity over 24h-d

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2
Q

Symptoms of delirium

A

May have poor memory, disorientation (often only oriented to self), long term memory, visuospatial ability, delusions and hallucination (often visual), often sus and persecutory prob, sleep/wake (reversed, no sleep)

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3
Q

Physio changes of delirium

A
  • meds (BDZs)
  • infx
  • F&E chx
  • hypoxia/ischemia
  • surgery
  • brain chx—dec cerebral fun or brain metab, inc plasma cortisol, NT imbalance, damage enzymes sys, BBB, cell membranes
  • kids—often meds or fever
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4
Q

Cardinal features of delirium

A
  • acute onset and fluc course
  • Dec ability to direct, focus, shift, sustain attn
  • disorg thinking
  • disturbance of consciousness
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5
Q

Assessment of delirium

A
  • cardinal features
  • cog and perceptual disturbance—illusion, hallucination
  • physical needs—help with ADLs
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6
Q

Nursing outcomes of delirium

A
  • safety
  • orientation
  • visual cues in enviro to orient
  • free from falls
  • pt/fam understand illness cause
  • continuity of care providers
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7
Q

Non-pharm tx for delirium

A
  • express fears and discomfort
  • comfort measures for trust
  • freq verbal orientation
  • freq brief interactions
  • consistent nursing staff
  • tv in day, off in night
  • nonverbal music
  • slowly approach pt and call name
  • good lighting
  • easy to read clock/calendar
  • Dec stim at night
  • Dec sleep disruptions, lower lights
  • provide physical safety
  • sx and supportive care (hydrate, nut, pain control, reassurance)
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8
Q

Pharm tx for delirium

A
  • very small dose of antipsychotics PRN
  • BDZs—watch for opp fx of agitation; better if hepatic probs
  • sleep—-mirtazapine
  • objective pain control; consider intermittent narcotics
  • ID drug-drug interactions
  • tx underlying causes
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9
Q

Communication with delirious pts

A
  • short simple sentences
  • speak low
  • ID self AAT and explain process
  • repeat questions if needed and leave time for response
  • educate pt when not conf and fam
  • call by name
  • repeat PRN
  • tell what to do, not what NOT to do
  • express fears
  • brief freq verbal orientation
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10
Q

dementia

A

degen, prog neuropsych dx resulting in cog, emo, bx, phys and dec fxn then death

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11
Q

Neurocog dx

A

Umbrella term including dementia
- prog dec of cog fxn and global impairment of intellect
- no LOC change
- acquired; not dev
- prob with memory, prob solving, complex attn, orientation, vocab, math, thinking abstractly

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12
Q

Mild neurocog dx

A

No interference with ADLs

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13
Q

Major neurocog dx

A

Interfere with daily fxn and ind
- examples Alz, vascular dementia, TBI, Parkinson’s, HIV, Hunt’s

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14
Q

Alzheimer’s

A
  • most common dementia
  • type of dementia that disturbs executive functions and is irreversible and progressive
  • often dx with r/o
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15
Q

Symptoms of Alz

A
  • aphasia—lose lang (receptive and expressive)
  • apraxia—lose purposeful mvt
  • agnosia—lose ability to recognize object/ppl - can’t remember family (measure with MMSE)
  • sundown in
  • confabulation—make things up to inc self-esteem
  • perseveration—repetition of words, phases, gestures
  • hyperorality—put things in mouth to taste and chew
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16
Q

Epidemiology of Alz

A
  • age 65+ and family
  • CVD
  • social engagement
  • diet
  • TBI
  • head injury
  • HTN and dyslipidemia
17
Q

Bio rf for Alz

A

Oxidative stress and free radicals precedes plaques
- inflammation after stroke (use of NSAIDs may Dec)

18
Q

Patho of Alz

A
  • Extracellular sticky beta-amyloid plaques (block synapses that are normally protected by tau proteins so nutrition can’t get into the cells and cells starve)
  • Intracellular neurofibrillary tangles—abnormal collections of tau proteins
  • brain atrophy and increase ventricle size
  • oxidative stress and free radicals
  • inflammation
19
Q

NTs in Alz

A
  • ACh (parasymp)—learn, memory, mood; prod decreases as disease progresses
  • Glutamate—cell signaling, learning, memory; inc in Alz (NMDA antags dec Ca by blocking NMDAr)
20
Q

Priorities for Alz tx

A
  • initial delay cog decline
  • moderate - protect pt from hurting self
  • late - phys needs become the focus of care
21
Q

Mild Alz sx

A
  • forgetful, misplaced stuff, Dec recall, social w/d, self-frustration
  • change might not be apparent except to spouse
22
Q

Mod Alz sx

A
  • Dec self-care, disoriented to time/place, wander, pace, delusions, hallucinations, Dec visual perception
  • accidents, need supervision, emotional mood swing
  • sx noticeable
23
Q

Severe Alz sx

A
  • often LTC
  • emotional self-care, long-term memory loss, lose language
  • incontinence, gait probs, sx, mute, can’t feed self
  • physical needs important
24
Q

Dementia assessment

A
  • biological—phys and ROS
  • phys fxn—sleep-wake, self-care, pain, nut, activity
  • psych—confab, perseveration, agraphia, hyperorality, aphasia, apraxia, agnosia, sundowning, sus, delus/halluc, illusions, anx, mood chx, catastrophic rxn
  • defense mechs—denial, confab, perseveration, avoidance
  • social—fxn, social sys, spiritual, QoL, primary caregiver, legal status
  • bx
25
Q

Behavioral s/s dementia

A
  • apathy and w/d
  • restless, agitate, agg
  • aberrant motor bx
  • disinhibition
  • hypersexuality
  • signs stress/anx
26
Q

Dementia dx

A
  • r/o metabolic dx
  • CT, PET, med, psych hx
  • MMSE
  • often only known in autopsy
  • review recent sx, meds, nut
27
Q

Interventions for confusion/agitation

A
  • speak clear, slow, direct
  • approach from front
  • face pt
  • 1 task at a time
  • patience!
  • nutrition—watch wt, intake, hydrate, watch for swallow prob
  • bowel/bladder fxn
  • para and nonverbal comm
  • walk if pt restless
  • pictures of pets, fam, wildlife
  • music they like (when young)
  • self-care but allow ind
  • sleep intx
  • balance activity with sleep
  • relax techniques
  • pain measures—don’t rely on verbalizing pain
28
Q

Acetylcholinesterase inhibitors

A
  • Galantamine for mild-mod
  • Donepezil and rivastigmine or transdermal patch (all stages)
  • used to delay not dec cog decline (stabilize memory, lang, orientation)
  • peak in 3M but continues to delay decline
  • minimal benefit after 1 year
29
Q

Benefit of the patch

A

Fewer GI prob

30
Q

Most common side effects of AChEI

A

N/V
- CNS dizzy, HA
- GI
- insomnia
- brady and syncope

31
Q

NMDAr anatgonist

A

Memantine
- restore fxn of damaged nerve cells and dec abnormal excitatory signals of the NT glut
- slow decline, slight inc in cog fxn
- used in all stages Alz and vasc dementia (mod-severe)
- block glut from NMDAr–prevent Ca from going into cells (NMDA normally binds and causes Ca to go into cell–dec abnormal signal of glut)

32
Q

NMDA antag SE

A

dizzy, confusion, HA, constipation

33
Q

Order of Alz meds

A
  • 1st ACh
  • 2nd NMDAr antag
  • can give both at once
34
Q

Off label meds for Alz

A

Start very low dose
- antipsychotics (may inc mort; be cautious)
- antidepressants
- antianx
- anticonvulsants