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BBE > Neuroblastoma > Flashcards

Neuroblastoma Flashcards

1
Q

Cuales son los tumores neuroplásticos

A

Neuroblastoma
Ganglioneuroblastoma
Ganglioneuroma

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2
Q

Que es un tumor neuroblastico

A

Tumor embrionario del SN simpatico, derivado de la cresta neural

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2
Q

Divisiones del neuroblastoma

A

Indiferenciado
En diferenciación
Poco diferenciado

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3
Q

Division del Ganglioneuroma

A

En maduración
Maduro

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3
Q

División de los Gangliosneuroblastomas

A

Entremezclado
Nodular

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3
Q

Que se necesita buscar para clasificar histológicamente

A

Celulas pequeñas, redondas y basofilas (azules)
Neuroblastos
Neuropilo
Celulas ganglionares
Estroma Schawanniano

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3
Q

Neuroblastoma indiferenciado

A

No hay celulas ganglionares
Neuropilo escaso

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4
Q

4 componentes importantes histológicos

A

Neuroblastos
Neuropilo
Estoma de Schwanniano
Células ganglionares

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5
Q

Neuroblastoma poco diferenciado

A

Neuropilo evidente (>5%)
Células ganglionares (>5%)

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6
Q

Neuroblastoma en diferenciacion

A

Neuropilo abundante
Celulas ganglionares

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6
Q

Ganglioneuroblastoma entremezclado

A

Estroma Schwanniano
Células ganglionares
Neuroblastos
Neuropilo

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7
Q

Ganglioneuroblastoma

A
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7
Q

Ganglioneuroma maduro

A

Estoma Schwanniano
Células ganglionares

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7
Q

Ganglioneuroma en maduracion

A

Estoma schwanniano
Células ganglionares
Neuroblasto

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8
Q

TrkA/ tipo 1

A

Propensos a diferenciacion y apoptosis
E-bajo
Edad <18 meses
Buen pronostico

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8
Q

TrkB / Tipo 2

A

Translocciones desequilibradas
Mal pronostico

8
Q

Ganancia desbalanceas de 17q

A

> 50%
Neuroblastoma agresivo

8
Q

DElecion 1p36

A

35% etapas avanzadas
Mayor riesgo de recaída en pacientes con tumores localizados y que carecen de amplificación N-MYC

9
Q

Delecion 11q

A

35-40%
Marcador predictivo de recaida

9
Q

Cuando se piensa en un tumor neuroblastico

A

Tumor/ distencion abdominal
Lesiones purpuricas subcutaneas
Microcalcificaciones en estudios de imagen

10
Q

Adordaje del neuroblastoma

A

Clinica
Bipsia
Radiologia
Grammagrafia con metayodobencilguanida
Catecolaminas en orina

11
Q

Estadificacion

A

1.- tumor licalizado sin ganglios
2.- reseccion incompleta
3.- ganglios ipsilaterales positivos
4.- Irresecable/ tumor que pasa linea media ganglios contralaterales
5.- metastasico

12
Q

Bajo grado

A

Ganglioneuroma
Ganglioneuroblastoma
Neuroblastoma diferenciado
<18 meses
MKI bajo

13
Q

Alto grado

A

Neuroblastoma indiferenciado
Neuroblastoma poco diferenciado
N-MYC amplificado
ALK
1p-

BBE (19 decks)

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