Neuroanatomy Reticular Formation & Cerebellum Flashcards
What is the central core of the brainstem?
the reticular formation
The reticular formation extends into the cerebrum as what?
the hypothalamus
The reticular formation (which extends into the cerebrum as the hypothalamus) is important in the regulation of what 6 things?
1) posture
2) some motor behaviors
3) the internal environment
4) pain
5) sleep and wakefulness
6) emotional tone
The three major cell columns of the reticular formation are what?
1) median reticular formation (raphe nuclei)
2) paramedian reticular formation (magnocellular neurons)
3) lateral reticular formation (parvocellular neurons)
What is the main sensory input to the reticular formation?
parvocellular nuclei
Point out the reticular formation
Does the limbic system input to the reticular formation? If so, what areas contribute to its input?
yes, and the input comes from the hippocampus, the amygdala, and prefrontal cortex
Are the outward projections from the reticular formation afferent or efferent?
efferent, to the spinal cord, limbic system, and all of the cortex
What part of the brain is serotonin associated with?
The raphe nuclei which projects to all regions of the cortex. Serotonin minimizes distractions, is involved with day-night cycle, suppresses pain, elevates mood, and is a common element in antidepressant medications (SSRIs)
What part of the brain is dopamine associated with?
Substantia nigra which projects to basal ganglia and is important in motor control
What is an easy way to remember the function of dopamine?
DOpamine “DOes” things
Identify the ventral tegmentum and the substantia nigra
Dopamine is associated with mesolimbic fibers and mesocortical fibers. To where do each project and what is associated with each?
mesolimbic fibers project to the limbic system and nucleus accumbens (signals emotional reward, is involved in drug dependency, and schizophrenia)
mesocortical fibers project to the entire cerebral cortex; especially the prefrontal lobe (organized thinking and planning [schizophrenia] )
The locus cerules, associated with norepinephrine, projects where and does what?
projects to the entire cerebral cortex and alerts cortex to novel stimuli (potential threats)
The ventrolateal medulla, associated with norepinephrine, projects where and does what?
projects to the spinal cord and inhibits pain
What two places in the brain is acetylcholine associated with
dorsolateral pontine tegmentum (important in ascending reticular activating system and control of sleep and wakefulness)
basal forebrain (basal nucleus) (supports cognition which is lost in alzheimers)
Where is the ascending reticular activating system?
dorsolateral pontine tegmentum (ACh, NE, and 5HT)
To what two organs do the fibers of the ascending reticular activating system go?
1) thalamus (to alert the cerebral cortex and maintain wakefulness)
2) preoptic portion of the hypothalamus (to block sleep)
Inhibition of activity of the preoptic area of the hypothalamus produces what result?
wakefulness, associated with the ASCENDING reticular activating system
Activity in what organ helps MAINTAIN the state of wakefulness (in contrast to the preoptic area of the hypothalamus PRODUCING wakefulness)
the lateral hypothalamus MAINTAINS wakefulness
Once every 24 hours, the _____ area of the _____ becomes dominant and switches off the dorsolateral pontine tegmentum to produce sleep
preoptic, hypothalamus
Precalculated rhythmic motor patters are associated with which three activities?
1) locomotion (gigantocellular nuclei)
2) eye movement control (paramedian pontine reticular formation)
3) chewing (supratrigeminal nucleus)
The supratrigeminal nucleus alternates activation between what two things?
jaw opening and jaw closing muscles
What are two theories that desribe bruxism activities?
1) malocclusion
2) sleep disorders