Neuroanatomy of Taste and Olfaction Flashcards
What type of receptors are odorant receptors?
GPCRs - ligand binding
What are the olfactory fila?
Axons from the olfactory receptor neuron passing through the lamina propria and cribiform plate to the olfactory bulb
What is the specificity of the olfactory receptor neurons?
Only express one type of odorant receptor that is processed in the olfactory bulb in the matching zone (individual glomeruli are thought to process different types of odors)
What is the first structure contacted by olfactory receptor neurons after passing through the cribiform plate?
Olfactory glomerulus
What are the layers of the olfactory bulb from superficial to deep?
- Olfactory nerve layer
- Glomerular layer
- External plexiform layer
- Mitral cell layer
- Granule cell layer
What cells do the olfactory receptor neurons synapse with in the glomerular layer?
Mitral and tufted cells
What cell layer contains the cell bodies of tufted cells?
External plexiform layer
How do granule cells moderate olfactory bulb activity?
Inhibitory feedback loop, release GABA into synapses w/ mitral and tufted cells
What is the hallmark of the olfactory bulb?
Projects directly to the cortex, skips the thalamus
What structure do the axons of the lateral olfactory tract contact to communicate with the contralateral olfactory tract?
Anterior olfactory nucleus
What embryological structure contains the olfactory cortex?
Telencephalon
What are the areas of the olfactory cortex?
Anterior olfactory nucleus
Olfactory tubercle
Piriform cortex
Anterior cortical amygdaloid nucleus
Periamygdaloid cortex
Lateral entorhinal cortex
What is the role of the orbitofrontal cortex?
Integrates olfactory with taste to produce flavors
What part of the thalamus receives olfactory information from the cortex?
Dorsomedial nucleus of the thalamus
What structures does the lateral hypothalamus receive olfactory input from? What behaviors does this influence?
Piriform cortex and anterior olfactory nucleus
Feeding behavior