Cerebellum Flashcards

1
Q

What layer of grey matter contains the cell bodies of basket cells and stellate cells?

A

Molecular layer

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2
Q

What is the deepest layer of grey matter? What cells does it contain?

A

Granular layer

Contains granule cells and a few Golgi cells

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3
Q

What are the efferent fibers from the cerebellar cortex?

A

Purkinje fibers

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4
Q

Most gray matter neurons tend to be ____ and use the NT ____, except for granule cells.

A

Inhibitory

GABA

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5
Q

What nuclei are inhibited by Purkinje cells?

A

Cerebellar and vestibular nuclei

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6
Q

Which neurons are the smallest? What NT does it use?

A

Granule cells

Glutamate

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7
Q

What grey matter cells synapse with Purkinje cells? What is their action?

A

Stellate cells and basket cells

Inhibitory

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8
Q

What are the afferent neurons in the gray matter? What is their general action?

A

Climbing fibers and mossy fibers

Excitatory

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9
Q

Where do the gray matter afferents send collateral branches?

A

Deep cerebellar nuclei

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10
Q

Where do the climbing fibers arise from?

A

Inferior olive

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11
Q

What cells do the climbing fibers synapse with?

A

Purkinje cells

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12
Q

What afferent fiberrs convey information about movement errors to the cerebellum?

A

Climbing fibers

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13
Q

What afferent fibers synapse with granulocytes?

A

Mossy fibers

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14
Q

What information do the mossy fibers convey?

A

Somatosensory, arousal, equilibrium, cerebral cortex motor info to cerebellum

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15
Q

What is the function of the vestibulocerebellum?

A

Influence eye movement and postural ms. of head and body

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16
Q

What is the anatomic name of the vestibulocerebellum?

A

Flocculonodular lobe

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17
Q

What information is transmitted to the flocculonodoluar lobe? Where does it send information to?

A

Receives info from vestibular receptors and visual areas

Sends ouput to vestibular nuclei

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18
Q

What is the functional name for the vermis and paravermal region of the cerebellum?

A

Spinocerebellum

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19
Q

What part of the spinocerebellum is associated with the medial upper motor neurons?

A

Vermis

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20
Q

What part of the spinocerebellum is associated with the lateral upper motor neurons?

A

Paravermal region

21
Q

What is the function of the vermis and paravermal region?

A

Control ongoing movement via brainstem descending tracts

Monitors gait and station

22
Q

What information is conveyed by the spinocerebellum?

A

Somatosensory info, internal feedback from spinal interneurons and sensorimotor cortex

23
Q

What is the functional name of the lateral hemispheres of the cerebellum?

A

Pontocerebellum/Cerebrocerebellum

24
Q

What is the function of the cerebrocerebellum?

A

Coordination of planned, timed, voluntary movements

Fine movements for fractionation

25
Q

What part of the cerebellum do the cerebral cortex and pontine nuclei send their information?

A

Pontocerebellum/Cerebrocerebellum

26
Q

The dorsal Nucleus of Clark is found at what spinal levels?

A

C8-L2

27
Q

What do the restiform and juxtarestiform bodies comprise?

A

Inferior cerebellar peduncle

28
Q

Which cerebellar tracts carries unconscious proprioception from the lower limb?

A

Anterior and posterior spinocerebellar tracts

29
Q

Where does the first order neuron of the posterior spinocerebellar tract enter, ascend through, and then synapse?

A

DRG => Gracile fasciculus => Nucleus dorsalis of Clark (C8-L2)

30
Q

What do the axons of the cuneocerebellar tract carry?

A

Unconscious proprioception from the upper limb

31
Q

Where do the first order neurons of the cuneocerebellar tract enter, ascend, and then synapse?

A

Enter via DRG => Ascend in cuneate fasciculus => Synapse in accessory/external/lateral cuneate nucleus (lower medulla)

32
Q

What is the path of the anterior spinocerebellar tract?

A
  1. Lamina of dorsal horn
  2. Crosses Anterior White Commissure to contralateral side
  3. Ascends through Anterior spinocerebellar tract
  4. Enters cerebellum through superior cerebellar peduncle
  5. Crosses back to ipsilateral side
33
Q

Where do the posterior spinocerebellar and cuneocerebellar tracts enter the cerebellum?

A

Inferior cerebellar peduncle

34
Q

Afferents from what enter the cerebellar cortex via the middle cerebellar peduncle?

A

Pontine Nuclei

35
Q

Afferents from what structures enter the cerebellar cortex via the inferior cerebellar peduncle?

A

Inferior olive

Spinal cord

Vestibular nuclei

36
Q

The efferents of the deep cerebellar nuclei mainly pass through what structure?

A

Superior cerebellar peduncle

37
Q

What are the interposed nuclei?

A

Globose and Emboliform nuclei

38
Q

Where would the lesion be if the patient was unable to tandem walk?

A

Vestibulocerebellum

(Also probably spinocerebellum)

39
Q

Patient is seen sitting in his bed, appears to be shaking and is unable to sit still. Upon examination, he has nystagmus and is unable to walk with one foot in front of the other. Where is his lesion?

A

Vestibulocerebellum

40
Q

Disease in what structures can cause midline ataxia?

A

Vestibulocerebellum

Spinocerebellum

41
Q

Patient is asked to walk around the room and appears to have a wide stance and staggering gait. Normal eye exam and has normal speech. Where is his lesion?

A

Spinocerebellum

42
Q

What is dysdiadochokinesia?

A

Inability to rapidly alternate movements

43
Q

What is dysmetria?

A

Inability to accurately move an intended distance

44
Q

What is an action tremor?

A

Intention tremor: shaking of the limb during voluntary movement, especially at the end of the movement

45
Q

Upon a patient examination, he tells you the history with slow, poorly articulated speech. He is unable to rapidly flip his hands back and forth, and appears shaky when touching his nose and then your finger. What disorder is this? Where is the lesion located?

A

Appendicular ataxia

Cerebrocerebellum

46
Q

A positive Romberg test with eyes open and closed is indicative of what disorder?

A

Cerebellar ataxia

47
Q

What is the difference between cerebellar and sensory ataxia?

A

Cerebellar - normal vibration, proprioception, and ankle reflexes, + romberg with both eyes open and closed

Sensory - abnormal vibration, proprioception, ankle reflexes, +romberg only with eyes closed

48
Q

How do you test vestibulocerebellum and spinocerebellum?

A

Station

Walking

Tandem gait

49
Q

How do you test cerebrocerebellum?

A

Rapid alternating movements

Finger-to-nose

Toe-to-finger

Heel-to-shin

Rebound and check reflex

Speech