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Y2S2 - Neurobiology > Neuro7 - 31 > Flashcards

Neuro7 - 31 Flashcards

1
Q

Why is tube to laminae an important transition?

A

Major conditions can arise, correlates highly with migration abnormalities

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2
Q

What is lissencephaly?

A

Smooth brain (agyria)

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3
Q

How thick is the neural tube initially?

A

One cell

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4
Q

How do neural cell types divide?

A

Nuclear translocation

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5
Q

When does division massively increase?

A

Massively after neuropores close

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6
Q

What is secreted by the Cajal-Retzius cells?

A

Reelin

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7
Q

What is reelin?

A

3460 a/a ECM-like protein

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8
Q

What is reelin named after?

A

Reeler mouse mutant - motor deficit leads them to reel around, as if drunk

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9
Q

What make the reeler mouse reel?

A

Lack of cortical layers - similarities to lissencephaly

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10
Q

What is Cajal-Retzius cell development regulated by?

A

Foxg1

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11
Q

What does Foxg1 -/- have?

A

Extra CR cells

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12
Q

Define macrodevelopment

A

Inside-out development

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13
Q

What is neural cell movement most often associated with?

A

Radial glia

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14
Q

When do most radial glia appear?

A

After development

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15
Q

Which radial glia don’t appear after development?

A

Bergmann glia - in the cerebellum

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16
Q

Where do radial glia run from and to?

A

Ventricular to outer layers - like spokes

17
Q

How are cortical glia described?

A

Tangential - run perpendicular to radial glia

18
Q

Outline cerebellar system of cells

A

External surface, molecular (relative cell free), big cells (Purkinje), dense granular layer

19
Q

Where does the cerebellum develop?

A

Boundary of mid and hindbrains, on roof of 4th ventricle

20
Q

What seperates the cerebellum from the 4th ventricle?

A

Medullary vellum

21
Q

What forms the geminal trigone?

A

Rhombic cells at superior and inferior edges of medullary velum

22
Q

What form the external germinal layer of the cerebellum?

A

Superior rhombic lip cells

23
Q

What form the pontine nuclei and inferior olive?

A

Inferior lip cells

24
Q

What does the external germinal layer of the cerebellum form?

A

Granule cells - neurons

25
Q

What regulates production of rhombic lip cells?

A

MATH-1

26
Q

What is MATH-1?

A

Transcription factor

27
Q

What does MATH-1 -/- have?

A

No foliaition, no internal granule layer, no pontine nuclei

28
Q

What stimulates mitosis in EGL?

A

SHh

29
Q

What is reelin supposed to do with regard to the EGL?

A

Stop migration into EGL, but it’s more complex

30
Q

What is pontocerebellar hypoplasia?

A

Pons and cerebellum don’t form correctly

31
Q

What causes pontocerebellar hypoplasia?

A

Problems with MATH-1

Y2S2 - Neurobiology (17 decks)

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