Neuro14 - 12

Question 1

How many neurons are lost in development?

Answer 1

50%

Question 2

Characterise most death in the nervous system

Answer 2

Deliberate

Question 3

Where does death in the nervous system occur?

Answer 3

Everywhere but motorneurons, pre and post synaptically

Question 4

How does most nervous system death occur?

Answer 4

Apoptosis - inhibited by actinomycin D or cycloheximide

Question 5

How is the remnants of nerves cleaned up?

Answer 5

Macrophages or neuritic disintegration and removal

Question 6

Pro-apoptotic genes

Answer 6

ced-3 + 4

Question 7

Anti-apoptotic genes

Answer 7

ced-9, bcl-2

Question 8

Triggers of developmental apoptosis

Answer 8

Lack of trophic support, absence of depolarising stimulus

Question 9

Why are neurons on a knife edge?

Answer 9

Neurotophins give pro and anti-apoptotic signals. Neurons need not only the right NTs, but also a lack of the wrong ones

Question 10

What does MK801 do?

Answer 10

Removes/disturbs NMDA activity, which leads to degeneration of neurons, increasing apoptosis

Question 11

What does STAU do?

Answer 11

Evokes apoptosis in hippocampus in vitro

Question 12

How can STAU be modulated?

Answer 12

Reduction in effectiveness by blocking GABA with bicucculine