Neuro15 - 7

Question 1

Example of synaptic refinement by loss

Answer 1

Climbing fibre loss - reduction from 4:1 purkinje to 1:1

Question 2

Example of synaptic refinement by focussing

Answer 2

Reorganisation of CF - initial contacts on soma, late on dendrites

Question 3

Example of synaptic refinement by connection focussing

Answer 3

Ocular dominance columns - immature not segregated, mature to layer iV are

Question 4

Example of synaptic refinement by focussing by competition

Answer 4

Establishment of ODC - monocoluar deprivation leads to spreading of non-deprived inputs

Question 5

Example of synaptic refinement by turning on synapses

Answer 5

Silent, intact but non-functional synapses can be turned on, i.e. NMJs. May be by AMPAfication

Question 6

What does APV do?

Answer 6

Blocks NMDA receptors

Question 7

What does blocking of NMDA receptors do?

Answer 7

Blocks delivery of GLUR1