Neuro3 - 20 Flashcards
What are the three developmental brain compartments?
Prosencephalon, mesencephalon, rhombencephalon
What does the prosencephalon become?
Telencephalon and diencephalon
What does the mesencephalon become?
Remains the same
What does the rhombencephalon become?
Metencephalon and myelencephalon
How is the neural tube patterned?
Activation-transformation
Outline activation-transformation
Neural-inducing molecules induce and maintain anterior forebrain, but only in the prechordal tissue; other signals, antagonised by the prechordal tissue, pattern posterior
Who and how was it determined that A-P neural patterning could be uncoupled?
Otto Mangold - late graft would only induce either A or P neural
What is anencephaly?
No forebrain
What acts to posteriorise the embryo?
Wnt, FGF and RA
What balances the posteriorising signals to maintain an anterior identity?
BMP and Wnt inhibitors
3 Wnt inhibitors
Cerberus, dickkopf, frzb1
How do posteriorising factors exert their action?
TFs called Hox genes
What does Hox stand for?
Homeobox
What does hox DNA code for?
Homeodomain of 60 a/a
What is the hox patterning system?
Conserved along AP axis in time and space
