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Y2S2 - Neurobiology > Neuro13 - 20 > Flashcards

Neuro13 - 20 Flashcards

1
Q

What are neurotrophins?

A

Trophic factors for neurons - family of chemicals required for keeping neurons alive

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2
Q

Why do lots of synapses fail and die?

A

Changes in survival due to amount of target tissue

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3
Q

What is the primary determinant of synaptic viability?

A

Co-ordinated electrical activity pre and post

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4
Q

What does uncoordinated synaptic activity lead to?

A

More losers

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5
Q

What does a TTX cuff do to muscle innervation?

A

Blocks pre input - no competition, so no losers

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6
Q

What does curare do to muscle innervation?

A

Prevents contraction, thus no post feedback, thus uncoordinated activity

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7
Q

What is NGF?

A

Nerve growth factor

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8
Q

Where is NGF purified from?

A

Snake venom and mouse salivary gland

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9
Q

Stucture of NGF?

A

Pentamer - 7S-NGF - 2a, b, 2g; OR dimer - B-NGF - alpha/gamma

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10
Q

How does NGF work generally?

A

Binds receptors, internalised, transported to soma (retrograde transport)

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11
Q

What are the NGF mechanics?

A

Binds low(p75) and high(TrkA) affinity receptors

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12
Q

How does TrkA work?

A

Dimerises to produce complex signalling over a matter of feet

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13
Q

What is BDNF?

A

Brain derived neurotrophic factor - high homology to NGF

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14
Q

What do all neurotrophins bind?

A

P75

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15
Q

What do placodal sensory ganglia prefer?

A

BDNF and NT3

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16
Q

What do crest-deriven DRGs prefer?

A

NGF

17
Q

What do Ruffini afferents prefer?

A

BDNF

18
Q

What do Merckel cells prefer?

A

NGF, NT3 and p75

19
Q

What is interested about neurotrophins in Drosophila and C. elegans?

A

No neurotrophins

20
Q

What other systems work as neurotrophins in Drosophila and C. elegans?

A

Glia-derived neurotophic factors, cytokines, hepatocyte GF, macrophage stimulated protein

Y2S2 - Neurobiology (17 decks)

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