Neuro p. 500-502 Flashcards
BALSA mneumonic stands for what? It treats what?
Parkinsons
Bromocriptine Amantadine Levodopa (with carbidopa) Selegiline (and COMT inhibitors) Antimuscarinics
Pt suffering from Parkinson for a decade presents with atrial fibrillation and diminished voluntary movements following administration of the medicine but postural instability in between. what medication is he on?
l-dopa (levodopa)/carbidopa
Name a NMDA receptor antagonist that helps prevent excitotoxicity (mediated by Ca2+)?
Memantine used for Alzheimer
Name 2 Non-ergot (preferred) Tx for Parkinson?
pramipexole (restless leg syn Tx), ropinirole
Pt with dec GABA, decr ACh, incr dopamine is prescribed a drug that inhibits VMAT. Name the drug and its use?
Tetrabenazine (tx Turetts)
Tx of Huntington disease
The drug that treats “1 Big Damn Headache” is contraindicated in which pts?
Triptans - 5-HT1B/1D agonists
patients with CAD or Prinzmetal angina
Which drug incr dopamine release and decr reuptake?
Amantadine
MOA of galantamine?
AChE inhibitors
Which drug can be used both in Schizophrenia (primarily positive symptoms) and Huntington dz?
Haloperidol—D2 receptor antagonist
Which agent blocks DOPA decarboxylase?
carbidopa
Which drugs prevent peripheral l-dopa degradation to 3-O-methyldopa (3‑OMD) by inhibiting COMT?
Entacapone, tolcapone
Drug that blocks conversion of dopamine into 3-MT by selectively inhibiting MAO-B?
Selegiline
2 MOA of Tolcapone
—blocks conversion of dopamine to DOPAC by inhibiting central COMT
—prevent peripheral l-dopa degradation to 3-O-methyldopa (3‑OMD) by inhibiting COMT.
Which Tx improves tremor and rigidity but has little effect on bradykinesia?
Benztropine/ Antimuscarinic (Tx for drug-induced Parkinson)
