Micro p.162-166 Flashcards
Neg stranded RNA virus must have what in order to replicate?
its own RNA-dependent RNA polymerase
6 Neg stranded RNA virus are:
“Always Bring Polymerase Or Fail Replication”
Arenaviruses, Bunyaviruses, Paramyxoviruses, Orthomyxoviruses, Filoviruses, Rhabdoviruses
T or F? Segmented viruses are all RNA viruses.
T
Which viruses are able to mutate frequently?
“BOAR “
Segmented viruses: Bunyaviruses, Orthomyxoviruses (influenza viruses), Arenaviruses, Reoviruses
All Picornavirus are enteroviruses (fecal-oral spread) except
rhinovirus
Picornavirus can cause aseptic (viral) meningitis except for?
rhinovirus and HAV
Picornavirus includes:
Poliovirus, Echovirus, Rhinovirus,
Coxsackievirus, and HAV
Which Picornavirus is destroyed by stomach acid?
Rhinovirus
Symptoms of high fever, black vomitus, and
jaundice and eosinophilic apoptotic globules on liver
biopsy may be seen with which virus?
Yellow fever virus
Councilman bodies
Yellow fever virus has a reservoir of 2?
monkey or human
Yellow fever virus is transmitted by?
Aedes mosquitoes
Which virus causes global infantile gastroenteritis, and is a segmented dsRNA virus?
Rotavirus (a reovirus).
What time of the year in the United States is acute diarrhea prevelant and at which public ares?
during winter
day care centers, kindergartens
Rotavirus destroys which part of the intestine causing diarrhea? what gets lost?
Villous atrophy leads to absorption of Na+ and loss of K+.
Which viral infection can result in pulsus paradoxus 2°
to upper airway obstruction?
Severe croup
What is Steeple sign and where is it seen?
Narrowing of upper trachea and subglottis on x-ray of neck
croup
Vitamin A supplementation can reduce which viral infection’s mortality in malnourished or vitamin-deficient
children?
Measles
Lymphadenitis with Warthin-Finkeldey giant
cells is seen in?
Measles
Pathology that is rarely seen in immunosuppressed pts with Measles?
giant cell pneumonia
T or F? Koplik spots follows the measles rash by 1–2
days.
F, it precedes it
What path can occur years later after Measles infection?
subacute sclerosing panencephalitis,
H. influenza virus contain 2 types of antigens called? .
hemagglutinin
neuraminidase
H. influenza virus antigens: hemagglutinin promotes —- and
neuraminidase promotes —- .
viral entry
progeny virion release
How does H. influenza v. cause a drift?
An antigenic drift causes changes based on random mutation in hemagglutinin or neuraminidase genes.
How does H. influenza v. cause pandemics?
Reassorts it’s viral genome segments, such as when segments of human flu A virus reassort with swine flu A
virus.
which 2 viral infections can predispose pt to superinfections?
H. influenza v., HBV (p166)
A “blueberry muffin” appearance with congenital rubella findings is indicative of?
extramedullary hematopoiesis
30 year old male remembers acquiring aseptic meningitis as a child, which might be related to his infertility. what is the causal virus?
Mumps virus (maybe do to Orchitis: inflammation of testes),
Why is H. influenza Live attenuated vaccine administered intranasally?
Because it contains temperature sensitive
mutant that replicates in the nose but
not in the lung
Paramyxoviruses contain ——— , which
causes respiratory epithelial cells to fuse and form multinucleated cells.
surface F (fusion) protein
Pt who is unable to swallow his saliva do to hydrophobia might have what viral infection?
Rabies virus
Negri bodies are commonly found in 2 places:
Purkinje cells of cerebellum and in hippocampal neurons
3 cell types that Ebola virus targets:
targets:
endothelial cells
phagocytes
hepatocytes
key to preventing Ebola transmission is:
Strict isolation of infected individuals and
barrier practices for health care workers
All Hepatitis viruses are RNA except for:
HBV
T or F? Pt infected with rabies start showing symptoms in less than a week.
Rabies has long incubation period (weeks to
months) before symptom onset.
2 hepatitis viruses that use the Fecal-oral rout for transmission:
HAV
HEV
Which hep virus uses a DNA polymerase that has both DNA- and RNA-dependent activities
HBV
Which hep virus is Primarily transmitted through
IVDU, posttransfusion?
HCV
Hep virus causing high mortality in pregnant women?
HEV
Which 2 hep viruses are transmitted parenteral,
sexual and perinatal?
HBV, HDV
