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M2015/16 > Immuno p.218-220 > Flashcards

Immuno p.218-220 Flashcards

1
Q

Blocks T-cell activation by preventing IL-2 transcription?

A

Cyclosporine

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2
Q

Tx for rheumatoid arthritis, Crohn disease and glomerulonephritis?

A

Azathioprine

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3
Q

Drug that is a mTOR inhibitor?

A

Sirolimus (Rapamycin

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4
Q

SE of which Immunosuppressants cause edema, hypertension, tremor?

A

Daclizumab, basiliximab

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5
Q

SE of which Immunosuppressants cause hypertension,

cataracts, avascular necrosis?

A

Glucocorticoids

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6
Q

Monoclonal antibodies that block IL-2R?

A

Daclizumab, basiliximab

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7
Q

Calcineurin inhibitor that binds FK506 binding

protein (FKBP)?

A

Tacrolimus (FK506)

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8
Q

SE of Tacrolimus?

A

 risk of diabetes and neurotoxicity

Nephrotoxic

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9
Q

Drug that is also used in drugeluting stents?

A

Sirolimus (Rapamycin)

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10
Q

Which Immunosuppressants causes gingival hyperplasia and hirsutism, nephrotoxicity?

A

Cyclosporine

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11
Q

SE of both calcineurin inhibitors?

A

highly nephrotoxic.

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12
Q

Epoetin alfa is used for?

A

Anemias (especially in renal failure)

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13
Q

Oprelvekin is which IL?

A

IL-11

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14
Q

Tx for Multiple sclerosis?

A

IFN-β

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15
Q

Difference between Filgrastim and

Sargramostim used for recovery of bone marrow?

A

Filgrastim (G-CSF)

Sargramostim (GM-CSF)

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16
Q

Recombinant cytokine used for renal cell carcinoma and metastatic melanoma?

A

Aldesleukin (IL-2)

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17
Q

Tx for Chronic hepatitis B and C, Kaposi sarcoma,

malignant melanoma?

A

IFN-α

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18
Q

Rituximab targets:

A

CD20

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19
Q

Trastuzumab targets:

A

HER2/neu

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20
Q

Cetuximab targets:

A

EGFR

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21
Q

Alemtuzumab targets:

A

CD52

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22
Q

Bevacizumab targets:

A

VEGF

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23
Q

Natalizumab targets:

A

α4-integrin

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24
Q

Eculizumab targets:

A

Complement protein C5

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25
Q

VEGF is targeted by 2 drugs:

A

Bevacizumab, Ranibizumab

26
Q

Denosumab targets:

A

RANKL

27
Q

Abciximab targets:

A

Platelet glycoproteins IIb/IIIa

28
Q

Palivizumab targets:

A

RSV F protein

29
Q

Adalimumab, Certolizumab, Infliximab target:

A

Soluble TNF-α

30
Q

Abciximab targets:

A

Platelet glycoproteins IIb/IIIa

31
Q

All TNF-α inhibitors predispose to infection, including reactivation of —-, since TNF is important in —– formation and stabilization.

A

latent TB

granuloma

32
Q

—- is a Fusion protein (receptor for TNF-α + IgG1 Fc),

produced by recombinant DNA.

A

Etanercept

33
Q

2 Therapeutic antibodies against CLL?

A

Alemtuzumab, Rituximab

34
Q

Therapeutic antibodies against dz that has lost the APC gene function?

A

Bevacizumab, Cetuximab

35
Q

Therapeutic antibodies against cancer that has lost VHL gene func?

A

Bevacizumab

36
Q

Therapeutic antibodies against head and neck ca?

A

Cetuximab

37
Q

Therapeutic antibodies against B-cell non-Hodgkin

lymphoma,?

A

Rituximab

38
Q

3 Therapeutic antibodies against rheumatoid

arthritis?

A

Rituximab
Adalimumab
Certolizumab
Infliximab

39
Q

Therapeutic antibodies against psoriasis, ankylosing spondylitis?

A

Adalimumab
Certolizumab
Infliximab

40
Q

Therapeutic antibodies against Neovascular age-related

macular degeneration?

A

Ranibizumab

Bevacizumab

41
Q

Therapeutic antibodies against Allergic asthma; prevents IgE binding to FcεRI?

A

Omalizumab

42
Q

Therapeutic antibodies against Multiple sclerosis?

A

Natalizumab

43
Q

Therapeutic antibodies against Paroxysmal nocturnal

hemoglobinuria?

A

Eculizumab

44
Q

Therapeutic antibodies against Antiplatelet agent for
prevention of ischemic complications in patients
undergoing percutaneous coronary stenting?

A

Abciximab

45
Q

Therapeutic antibodies against Breast cancer?

A

Trastuzumab

46
Q

Therapeutic antibodiesthat inhibits osteoclast

maturation (mimics osteoprotegerin)?

A

Denosumab

47
Q

T or F? Etanercept is a decoy TNF-α receptor and a monoclonal antibody.

A

F. It is NOT a monoclonal antibody.

48
Q

2 Therapeutic antibodies against Crohn disease/IBD?

A

Natalizumab

Adalimumab, infliximab

49
Q

Therapeutic antibodies for RSV prophylaxis for high-risk infants?

A

Palivizumab

50
Q

Which Therapeutic antibodies causes WBC adhesion and Risk of PML in patients with JC virus?

A

Natalizumab

51
Q

Which 2 drugs inhibit the formation of NFAT–P into NFAT?

A

Calcineurin inhibitors:
Cyclophilin + Cyclosporine
FKBP + Tacrolimus

52
Q

Immunosuppressant that inhibit PRPP amidotransferase indirectly?

A

Azathioprine

53
Q

Which immunosuppressant causes apoptosis of T cells?

A

Glucocorticoids

54
Q

Mycophenolate, Mofetil MOA?

A

reversibly inhibits IMP dehydrogenase => prevent purine synth of B and T cells.

55
Q

Which 3 immunosuppressants cause hyperglycemia?

A

Mycophenolate, Mofetil

Glucocorticoids

56
Q

MOA of Glucocorticoids?

A

Inhibits NF-kB => decr cytokines transcription => decr T and B cell function.

57
Q

Which immunosup. causes pancytopenia?

A

Mycophenolate, Mofetil

58
Q

Which 3 immunosup. causes IL-2 response and which causes IL-2 transcription?

A

Preventing IL-2 response –> Sirolimus

Preventing IL-2 transcription –> Cyclosporin, Tacrolimus

59
Q

Which 2 immunosup. cause hyperlipidemia?

A

Sirolimus

Cyclosporin

60
Q

Which 3 immunosup. causes pancytopenia?

A

Azathioprine

Mycophenolate, Mofetil

61
Q

Name the drug that is a thrombopoetin receptor agonist?

A

Eltrombopag

62
Q

3 drugs that treat thrombocytopenia?

A

Romiplostim
Eltrombopag
Oprelvekin

“REOcytopenia”

M2015/16 (27 decks)

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