Musculoskeletal p. 440-443

Question 1

Exotoxin destroys keratinocyte attachments in — only vs. toxic epidermal necrolysis, which destroys —.

Answer 1

stratum granulosum

epidermal-dermal junction

Question 2

T or F? HSV1 and HSV2 can cause herpetic whitlow?

Answer 2

T (finger) (dentist and wrestlers)

Question 3

Which infection involving upper dermis and superficial lymphatics, usually from S. pyogenes?

Answer 3

Erysipelas

Question 4

Which infection causes multiple crops of

lesions in various stages from vesicles to crusts?

Answer 4

Varicella zoster virus

Question 5

Erythema multiforme is associated with which infections, paths and drugs?

Answer 5

Mycoplasma, pneumoniae, HSV
drugs: sulfa drugs, β-lactams, phenytoin
cancers
autoimmune disease

Question 6

A small, rough, erythematous or brownish papules or

plaques that inc the risk of squamous cell carcinoma is called what?

Answer 6

Actinic keratosis

Question 7

Hairy leukoplakia occurs in what kind of pt? What virus mediates it?

Answer 7

Occurs in HIV-positive patients, organ transplant recipients.
EBV mediated

Question 8

What is a more severe form of Stevens-Johnson syndrome with > 30% of the body surface area involved ?

Answer 8

toxic epidermal necrolysis

Question 9

Obese Pt with gastric adenocarcinoma may present with what type of kind disorder?

Answer 9

Acanthosis nigricans (hyperplasia of spinosum)

Question 10

Wickham striae seen in Lichen Planus refers to what?

Answer 10

Mucosal involvement manifestations, (reticular white lines)

Question 11

Lichen Planus is associated with what virus?

Answer 11

Associated with hepatitis C, HHV-8

Question 12

Erythema nodosum is associated with what 7 conditions?

Answer 12

sarcoidosis, 
coccidioidomycosis, 
histoplasmosis, 
TB, 
streptococcal infections, 
leprosy , 
Crohn disease

Question 13

Which environmental condition can lead to impetigo?

Answer 13

Sunburn

Question 14

— is dominant in tanning and photoaging, — in sunburn.

Answer 14

UVA

UVB

Question 15

“palisading” nuclei is see in:

“pseudopalisading” nuclei is seen in:

Answer 15

Basal cell tumors, Schwanomas

Glioblastoma multiforme, Neuroblastoma

Question 16

Ulcerative red lesions with frequent scale and associated with chronic draining sinuses describes what path?

Answer 16

Squamous cell carcinoma

Question 17

— is a variant of squamus cell carcinoma that grows rapidly (4–6 weeks) and may regress spontaneously over
months.

Answer 17

Keratoacanthoma

Question 18

Paths that are S-100?

Answer 18

Langerhans cell histiocytosis
Schwannoma
Melanoma

Question 19

keratin “pearls” seen in 2 paths?

Answer 19

Squamous cell carcinoma of lung

Squamous cell carcinoma of skin

Question 20

Pink, pearly nodules, commonly with —, rolled borders and central crusting or ulceration describes what path?

Answer 20

telangiectasias

Basal cell carcinoma (pears on the base of ocean)

Question 21

Which scaly plaque is precursor to squamous cell carcinoma?

Answer 21

Actinic keratosis

Question 22

BRAF gene mutation is seen in what 4 paths?

Answer 22

Serrated polyps
Papillary carcinoma of thyroid
Melanoma
Letterer-siwe

Question 23

At what diameter can we call a lesion melanoma?

Answer 23

Diameter > 6 mm

Question 24

Metastatic or unresectable melanoma in patients with — mutation can be treated with vemurafenib.

Answer 24

BRAF V600E (valine to glutamate)

Question 25

Name 4 types of melanoma?

Answer 25

superficial spreading
nodular - worst
lentigo maligna - older, multinucleated melanocytes
acral lentiginous - on feet or palmer surface

Question 26

Deposits of IgA at tips of dermal papillae is seen in what blistering skin disorder? What type of HS?

Answer 26

Dermatitis herpetiformis

HS type III

Question 27

What blistering skin disorder shows immunofluorescence of antibodies around epidermal cells in a reticular (net-like) pattern?

Answer 27

Pemphigus vulgaris

Question 28

Appoptosis of keratinocyes is seen in what skin disorder?

Answer 28

sunburn

Question 29

Erythema nodosum is lesion of what?

Answer 29

painful inflammatory lesions of subcutaneous fat