Neuro Flashcards

1
Q

What is the definition of homeostasis?

A

Dynamic constancy

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2
Q

What does negative feedback do?

A

An increase or decrease in a variable causes a response that moves variables in the opposite direction

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3
Q

What is positive feedback?

A

An accelerated, explosive system, and the feedback stops when the stimulus does

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4
Q

Birth, blood clotting, and sexual orgasm are examples of what type of feedback?

A

Positive

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5
Q

Responses to Na+ change, temperature change, and blood pressure changes are what type of feedback?

A

Negative

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6
Q

The stimulus strength affects spike height in action potentials or local potentials?

A

Local potentials

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7
Q

Stimulus strength affects frequency in action potentials or local potentials?

A

Action potential

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8
Q

What triggers local potentials?

A

Ligand binding

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9
Q

Which can sum, between action potentials and local potentials?

A

Local potentials

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10
Q

What causes voltage-gated ion channels to open?

A

Membrane depolarization

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11
Q

What opens the voltage gated Ca2+ channel of the presynaptic terminal?

A

The action potential and Na+ entry

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12
Q

What does calcium do in the pre-synaptic axon?

A

Helps synaptic vesicles fuse with the pre-synaptic membrane and release neurotransmitters

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13
Q

Which type of receptor is a receptor and a channel?

A

Ionotropic

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14
Q

Which receptor type is slow and longer lasting?

A

Metabotropic

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15
Q

What activates a metabotropic receptor?

A

Neutrotransmitter binds, activates g-proteins, g-proteins activate the receptor

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16
Q

What do G-proteins do?

A

Activate metabotropic receptors when stimulated by neurotransmitters

17
Q

What does cocaine inhibit the reuptake of?

A

Dopamine

18
Q

Which medication hyperpolarizes excited cells?

A

Anti-anxiety medication

19
Q

Which medication acts like GABA towards excited cells?

A

Anti-anxiety medication

20
Q

Which drug blocks the modulatory interneuron?

A

Dopamine

21
Q

Inhibitory or excitatory? NT binds to ionotropic receptor, chlorine flux. Chlorine high outside compared to inside

A

Inhibitory - negative ions coming in

22
Q

Excitatory or inhibitory? NT binds to metabotropic receptor, second messenger cascade closes a calcium channel

A

Inhibitory, loss of positive ion flux

23
Q

Calcium is high inside or outside cells?

A

Very high outside

24
Q

What is happening at rest at the sarcomere?

A

Tropomyosin is covering the myosin binding site on the actin

25
Q

Where is the myosin binding site?

A

Actin

26
Q

What causes tropomoysin to pull off the myosin binding site?

A

Calcium binds to troponin

27
Q

Acetylcholine binds to what receptor on the muscle cell endplate?

A

Nicotinic receptor

28
Q

What type of receptor is a nicotinic receptor?

A

Metabotropic

29
Q

What does the nicotinic receptor do on the muscle cell endplate?

A

Opens channels, Na+ influx

30
Q

The action potential propagates down the muscle cell membrane and hits what?

A

DHP membrane

31
Q

How is the Ryanodine receptor opened?

A

DHP changes conformation, communicates with and opens the Ryanodine receptor

32
Q

Where is calcium being held in the muscle cell?

A

Sarcoplasmic reticulum (SR)

33
Q

How does calcium exit the SR?

A

Ryanodine receptor on the SR opens to allow calcium into the muscle cell cytoplasm

34
Q

What is the calcium source for muscle excitation?

A

Extracellular