NERVOUS SYSTEM UNIT REVIEW Flashcards
Nervous system functions
Responsible for coordination of movement and to respond to environmental stimuli, intelligence, self-awareness, thought, and emotion
What are nerve cells composed of
Neurons
Neurons
Specialized to carry nerve impulses
What does it mean when the two nervous systems are ARBITRARY
Meaning that they both work together and are connected to one another
Two major divisions of nervous system:
- Central Nervous System (CNS)
- Peripheral Nervous System (PNS)
What is the central nervous system associated with
Brain and spinal cord
What is the peripheral nervous system associated with
The rest of the nervous system
Parts of a neuron (7):
- Dendrites
- Cell body
- Axon
- Myelin sheath
- Schwann cell
- Nodes of Ranvier
- Synaptic endings
Dendrites
Contains great surface area to pick up nerve impulse and conduct it towards cell body
Cell body
Metabolic centre of cell
What type of reactions occur in cell body
Cellular respiration and protein/lipid synthesis
Axon
Conducts nerve impulses away from cell body
Myelin sheath
Made of lipids and wraps around axon to insulate
Schwann cells
Produces myelin sheath. It contains tightly packed spirals of cell membrane
Nodes of Ranvier
Gaps in the myelin. It allows more rapid nerve conduction along axon
Synaptic endings
End of axon. Vesicles containing neurotransmitters are located here
3 types of neurons:
- Sensory neuron
- Motor neuron
- Interneuron
Sensory neuron
Takes a message from a sense organ to CNS
Another name for sensory neuron
Afferent neuron
What do sensory neurons contain
Long dendrites and short axon
Motor neurons
Takes message away from CNS to muscle fiber or gland
Another name for motor neuron
Efferent neuron
What do motor neurons contain
Short dendrites and long axon
Interneuron
Completely contained within CNS. Conveys messages between parts of the system
Another name for interneuron
Association neuron/connector neuron
What do interneurons contain
Long or short dendrites and axons (size varies)
Giant squid axon
Very large axon that controls part of the water jet propulsion system in squid to rapidly activate muscles of squid mantle
Nerve conduction is an _____
Nerve conduction is an ELECTRICLE IMPULSE
Direction of electrical impulse
One direction along length of nerve fiber
What do electrical impulses contain
Changes in voltage, as well as concentration of certain ions
Oscilloscope
Voltmeter that shows graph of voltage changes to measure potential differences
3 distinct phases of nerve impulse conduction/propagation:
- Resting potential
- Action potential
- Refractory period
Resting potential
Potential difference across the membrane of axon when it is not conducting an impulse
Voltage across membrane of axon at resting
-65v
Reasonings of negative polarity of resting
Due to presence of large organic negative ions (proteins) in the axoplasm
Na and K concentrations at resting
More Na ions on the outside of axon compared to inside, and more K ions on the inside compared to outside
How is the uneven distribution of Na and K maintained by
Active transport across Na+/K+ pump which operate whenever the neuron is not conducting an impulse
How are nerves in action potential stimulated
Through electric shock, pH change, or mechanical stimulation
Action potential
When nerve impulse is generated and a change in voltage occurs
Depolarization
When during UPSWING (-65mV to +40mV) the membrane becomes permeable due to Na channels opening and Na ions move from outside to inside of axon. It is called depolarization because the inside of axon becomes positive
Repolarization
When during DOWNSWING (+40mV to -70mV) due to K channels opening and K moves inside axon. It is called repolarization because the inside of axon becomes negative again
Refractory period
In between nerve impulses/transmissions, K ions are returned to inside of axon and Na to the outside back to original
How is transportation of refractory period achieved
Using active transport with carrier proteins
Step 1 of nerve impulse conduction/propagation
Sodium moves in; Sodium channels open and Na+ ions diffuse INTO axon
Step 2 of nerve impulse conduction/propagation
Depolarization; Inside of axon of specific region is now positive
Step 3 of nerve impulse conduction/propagation
Na+ channels close and K+ opens; Potassium channels open and K+ ions diffuse OUT of axon
Step 4 of nerve impulse conduction/propagation
Repolarization; Movement of K+ ions counters depolarization. The voltage difference across membrane returns to resting potential
Step 5 of nerve impulse conduction/propagation
Recovery period; Na+ and K+ actively transported back across membrane until concentrations are equally distributed as before impulse was sent (ATP STAGE USING CARRIER PROTEINS)
Step 6 of nerve impulse conduction/propagation
Depolarization of adjacent part of axon; Sodium channels open and Na+ ions diffuse into axon
Which stage uses ATP and why
Step 5 (recovery period) uses ATP for carrier proteins
Are nerve impulses rapid or slow
Rapid
What allows nerve impulses travel so fast
Myelin sheath serves as an electrical insulator to allow nerve impulses to travel fast and maintain high speed communication between nerve cells
What is myelin sheath formed of
Formed by tightly packed spirals of cell membrane of Schwann Cell
What are the interruptions or gaps of the myelin sheath called
Nodes of Ranvier
Myelin physical characteristics
White and shiny
Speed of transmission in myelinated fibres
200m/s
Speed of transmission in non-myelinated fibers
0.5m/s
Why are nerve impulses faster with myelinated fibers compared to non-myelinated fibers
Because the nerve impulses jumps from node to node in myelinated fibers. However, with non-myelinated fibers, the nerve impulse must depolarize and repolarize each point along the nerve fibre
Advantages of an organism with myelinated fibers (2):
- Respond to stimulus faster
- Think faster
Synaptic ending
Specialized regions at the ends of axons. They are swollen terminal knobs on the ends of axon terminal branches
Why are transmissions across a synapse one way
Because only the ends of axons have synaptic vesicles that can release neurotransmitters to affect the potential of the next neurons
Synapse
Region between end of an axon and the cell body/dendrite to which it is attached
Presynaptic membrane
Membrane of synaptic ending
Postsynaptic membrane
Membrane of the next neuron beyond axon’s synaptic membrane
Synaptic cleft
Space between the pre and past synaptic membranes
Synaptic vesicles
Contains neurotransmitters contained near surface of synaptic endings
Neurotransmitter substances
Chemicals that transmit the nerve impulses across a synaptic cleft
2 types of neurotransmitter substances:
- Excitatory transmitters
- Inhibitory transmitters
Excitatory transmitters and examples
Make post synaptic membrane more permeable to Na+. Eg. Adrenalin, dopamine, glutamine
Inhibitory transmitters and examples
Make post synaptic membrane less permeable to Na+. Eg. GABA (Gamma Amino Butyric Acid), glycine, serotonin
Sequence of events during synapse (8):
- Nerve impulse travels along axon and reaches synaptic ending
- Ca+ flows into ending through channel proteins
- Ca+ ions cause contractile proteins to pull synaptic vesicles to inner surface of presynaptic membrane
- Vesicle fuses with presynaptic ending and releases NT to synapse
- NT diffuse across synaptic cleft to receptor on postsynaptic membrane
- NT binding to specific receptors can open the ion channels
- Ion flux changes voltage of postsynaptic membrane and moves membrane voltage closer to threshold value required for action potential
- NT is degraded to prevent them from continually acting on postsynaptic membrane
How are neurotransmitters degraded (2):
- Enzymes such as acetylcholinesterase breaks down acetylcholine
- Synaptic ending reabsorbs the NT through endocytosis
Monoamine oxidase
Breaks down noradrenaline after absorbed
Neurotransmitters
Takes nerve impulses across synapses. They are small molecules
Examples of NT
Single amino acids, short chains of amino acids, or derivatives of protein
How is proper brain and nervous system function maintained
Through proper balance of excitatory and inhibitory synaptic transmitters
What does it mean when a single neuron may receive information from thousands of neighbouring neuron through thousands of synapse
Means that some of the messages can be excitatory (telling neurons to fire), while others may be inhibitory (telling neurons not to fire)
5 actions of drugs at synapse:
- Stimulates release of NT
- Blocks release of NT
- Combines with NT preventing its breakdown
- Mimics NT
- Blocks receptor so NT can’t be received
Drugs
Promotes or decreases action of NT by stimulating or inhibiting the actions of excitatory/inhibitory transmitters
Stimulants
Enhance excitatory transmitters or block action of inhibitory transmitters
Depressants
Enhance action of inhibitory transmitters or block action of excitatory transmitters
What does the peripheral nervous system consist of and why
Nerves that only contain long dendrites and/or long axons. This is because neuron cell bodies are only found in the brain, spinal cord, and ganglia
Ganglia
Collections of cell bodies within PNS
3 types of nerves:
- Sensory nerves
- Motor nerves
- Mixed nerves
What do sensory nerves contain
Long dendrites of sensory neurons
What do motor nerves contain
Long axons of motor neurons
What do mixed nerves contain
Both long dendrites of sensory neurons and long axons of motor neurons
Cranial nerves (3):
- Part of PNS
- All 3 types of nerves
- Head, neck, face, EXCEPT vagus nerve
How many pairs of cranial nerves are attached to brain
12 pairs
Spinal nerves (2):
- Mixed nerves
- Dorsal root and ventral root join just before spinal nerve leaves vertebral column
How many pairs of spinal nerves do humans have
31 pairs
Dorsal root
Identified by presence of an enlargement called dorsal root ganglion which contains cell bodies of sensory neurons whose dendrites conduct impulses towards spinal cord
Ventral root
Each spinal nerve contains axons of motor neurons that conduct impulses away from cord
Somatic nervous system
Includes all nerves that serve the musculoskeletal system and the exterior sense organs
Reflexes
Involuntary responses to changes occurring inside or outside the body
Reflex arc
Main functional unit of nervous system
5 steps to reflex action:
- Receptor is stimulated (temp, pain)
- Sensory neuron carries impulse through dorsal root ganglion to spinal cord
- Sensory neuron synapses with interneuron in gray matter of spinal cord
- Interneuron synapses with motor neuron
- Motor neuron carries impulse through ventral root to muscle/gland
Gray matter (3):
- Where synapses occur
- Interneurons located here
- Has 6 million cell bodies
White matter
Myelinated nerve tracts (bundle of axons)
Why do doctors test reflex with reflex hammer
To make sure your nerve-spinal cord pathway is functional
What components make up the autonomic nervous system
Divided into sympathetic and parasympathetic nervous system. The two systems connect to same organs but have opposite effects
Sympathetic and parasympathetic nervous system functions in the autonomic nervous system
Functions automatically on internal organs and utilizes two motor neurons and one ganglion for each nerve impulse
Sympathetic nervous system significance
Significant for emergency situations because it triggers your fight or flight
What are neurotransmitters released by in sympathetic nervous system
post-ganglionic axon
Where do post-ganglionic fibers of sympathetic nervous system arise in sympathetic nervous system
From middle part (Thoracic lumbar) of spinal cord
Long or short for preganglionic fiber and postganglionic fiber in sympathetic nervous system
Preganglionic is short and postganglionic is long
NT for sympathetic nervous system
Noreadrenaline
Parasympathetic nervous system function
Promotes all internal responses associated with a relaxed state
NT for parasympathetic nervous system
Acetylcholine
What are neurotransmitters released by in parasympathetic nervous system
Post-ganglionic axon
Where do post-ganglionic fibers of parasympathetic nervous system arise
Arise from upper and lower part of spinal cord (cranial and sacral nerves)
Long or short for preganglionic fiber and postganglionic in parasympathetic nervous system
Pre-ganglionic fiber is long and post-ganglionic fiber is short because the ganglia lies near or within organ
Weight of brain
3lbs
What makes up the central nervous system
Brain and spinal cord
Name of the protective membranes of CNS
Meninges
3 protective membranes of CNS
Dura mater, arachnoid, pia mater
What are the spaces in between meninges filled with and why
Cerebral spinal fluid for cushioning and protection
Facts about the brain
We had the maximum amount of neurons when we are born and thousands are lost daily
What does hindbrain refer to
Medulla oblongata
Where is medulla oblongata located
Closest to spinal cord
What does medulla oblongata control (8):
- Heart beat
- Breathing
- Blood pressure
- Coughing
- Sneezing
- Vomitting
- Hiccuping
- Swallowing
What does the cerebellum control
Balance and complex skeletal movement. It is responsible for painting normal muscle tone and posture
Where does the cerebellum receive sensory information from
Inner ear and medulla oblongata
Midbrain is an intersection of
Intersection of the forebrain, hindbrain and medulla oblongata
What does the forebrain refer to
Thalamus
Where does the thalamus receive sensory information from
All parts of the body. It receives all impulses except smell and sends them to appropriate regions of cortex
ARAS
The reticular activating system that sorts out incoming stimuli and passes them to cerebrum to information that requires immediate attention. So essentially it lets you ignore certain input
Where does the ARAS extend from
Medulla oblongata to the thalamus
Hypothalamus significance
Homeostasis by maintaining internal environment
Hypothalamus contains centres for.. (7):
- Hunger
- Thirst
- Body temp
- Water balance
- Blood pressure
- Sex drive
- Sleep
What does the hypothalamus control
Pituitary gland which serves as a gland between nervous system and endocrine system
Corpus callosum function
Transmits impulses between two cerebral hemispheres. (Right and left side of brain)
What does it mean if corpus callous is severed
Means that the two halves of the brain does not communicate with one another normally and will function separately
What does the conscious brain refer to
Cerebrum
Largest and most prominent portion of brain
Cerebrum
Name of outer layer of cerebrum
Cortex
What does the cerebrum do
Forms intellect, learning, memory, and sensations
What is the cerebrum divided into
Right and left cerebral hemispheres which contains 4 lobes
4 lobes of cerebrum:
- Frontal
- Parietal
- Temporal
- Occippital
Frontal lobe (4):
Problem solving, concentration, planning, movement of tongue and mouth
Parietal lobe (5):
- Touch
- Temp
- Pain
- Pressure
- Understanding speech
Temporal lobe (5):
- Hearing
- Smell
- Memory of visual scenes
- Music
- Interpretation of experiences
Occipital lobe
Vision
Right and left hemisphere of brain function
Right controls left side of body (except smell), and vice versa. An image viewed with the right eye is actually “seen” with then left occipital lobe
Left hemisphere of brain is referred to
Logical side
Right hemisphere of brain is referred to
Intuitive side