Nervous System Flashcards
Differences between nerves and hormones cell communications
Nerves is faster, localised, specific. Hormones is slower but effects last longer
Paracrine
1 -> few
Endocrine
1 to many
Autocrine
Feedback
Synapse
1 to 1
Electrical synapse
Contact via gap junctions, ions can flow in both directions
G proteins function
Since peptide transmitters cannot pass through the cell membrane, it binds to receptors on the surface and activates G proteins. These G proteins activate 2nd messenger systems such as cAMP and calcium ions
Calcium-calmodulin and cAMP as second messengers
Is the inside or outside of the cell more positive?
Outside of the cell. Therefore resting membrane potential is -70.
Sodium potassium pump
3 sodium ions out 2 potassium ions in
Depolarisation
Closer towards zero
Hyperpolarisation
Further away from zero
Action potential occurs at what membrane potential
-55. If below -55, just graded potential
When do voltage gated sodium ion channels shut
+35. Potassium channels open
Why is there Hyperpolarisation?
Potassium ion channels are slow to shut
What constitutes the refractory period?
Repolarisation (sodium ion channels shut) and Hyperpolarisation (potassium ion channels slow to shut)
How does local anaesthetic work?
Blocks the sodium ion channels from opening
What is EPSP
Excitatory post synaptic potential
IPSP
Inhibitory post synaptic potential. Transmitter causes Hyperpolarisation
Temporal and spatial summation
Spatial - many neurones connect to one neurone
Temporal - nerve impulses arrive in quick succession from the same presynaptic neurone
3 special features of NMJ
- Many folds in postsynaptic membrane to store AchE to return to presynaptic
- More receptors
- Ach is always excitatory
Organisation of nervous system
CNS brain and spinal cord
PNS cranial and spinal nerves
The name for autonomic pathway
Visceral Afferent and efferent
How many pairs of spinal nerves
31
How many pairs of cranial nerves
12
Name the 12 cranial nerves
Olfactory
Optic
Oculomotor
Trochlear
Trigeminal
Abducens
Facial
Vestibulocochlear
GGlossopharyngeal
Vagus
Accessory
Hypoglossal
Peripheral nerve histological components
Endo peri and epineurium
Grey matter
Unmyelinated
White matter
Myelinated. Rmb that myelin has fat so white
What are the different fibres and myelination of fibres
A fibres are myelinated c fibres are not. A fibres are much wider in the diameter
Dermatomes
The region where sensory nerves act
Myotomes
The region where motor nerves act