Nephritic Diseases Flashcards
What often causes a Nephritic Syndrome picture?
Glomerulonephritis
– inflammation of glomerulus
State how a Nephritic syndrome will present
PHAROH
- Proteinuria – MILD
- Hematuria
- Azotemia
- RBC casts
- Oliguria
- HTN
State how a Nephritic Syndrome will present
PHAROH
- Proteinuria – MILD
- Hematuria
- Azotemia
- RBC casts
- Oliguria
- HTN
What 3 findings are really shared between Nephritic and Nephrotic Syndrome?
Proteinuria
HTN
EDEMA
Initial evaluation for Nephritic/Nephrotic syndrome presentations?
UA +/- Renal Biopsy
What usually causes Post-infectious Glomerulonephritis?
Group A beta hemolytic Streptococcus Pyogenes infection
What 2 antibodies may be present with Post-Infectious Glomerulonephritis?
ASO
Anti-DNase
What will the level of C3 be with Post-Infectious Glomerulonephritis?
LOW C3!
How will the immunofluorescence look with Post-Infectious Glomerulonephritis?
Lumpy-Bumpy
What is the treatment for Post-infectious Glomerulonephritis?
Supportive; diuretics if fluid overloaded
How may IgA Nephropathy present?
Concurrent URI/GI infection + Nephritic signs
If a patient has Nephritic signs + URI/GI infection, what is the likely cause?
IgA Nephropathy
What will the level of C3 be with IgA Nephropathy?
NORMAL C3
What will be seen on immunofluorescence with IgA Nephropathy?
IgA deposits
What vasculitis disease presents with IgA nephropathy?
Henoch-Schonlein Purpura
What are the symptoms of Henoch-Schonlein Purpura?
IgA nephropathy – Nephritic signs
Palpable purpura
Arthralgias
Abdominal pain
What are the symptoms of Henoch-Schonlein Purpura?
IgA Nephropathy – Nephritic signs
Palpable purpura
Arthralgias
Abdominal pain
QUICK! What is affected with Granulomatosis with Polyangiitis?
Kidney
Lung
Sinus
How may Granulomatosis with Polyangiitis present?
Nephritic syndrome – Hematuria/HTN
Hemoptysis
Sinus symptoms
(+) C-ANCA or PR3-ANCA correlates to?
Granulomatosis with Polyangiitis
QUICK! What is affected with Microscopic Polangiitis?
Kidney
Lung
How may Microscopic Polangiitis present?
Nephritic syndrome – Hematuria/HTN
Hemoptysis
(+) P-ANCA or MPO-ANCA correlates with?
Microscopic Polyangiitis
QUICK! What is affected with Churg-Strauss Syndrome?
Kidney
Asthma
How may Churg-Strauss Syndrome present?
Nephritic syndrome – Hematuria/HTN
Asthma
Other non-specific signs
What cell type may be elevated with Churg-Strauss Syndrome?
Eosinophils
IgE
With Granulomatosis with Polyangiitis, Microscopic Polangiiits and Churg-Strauss Syndrome, what will be seen on light microscopy?
Crescents
What is Goodpasture syndrome?
Anti-GBM antibodies that causes rapidly progressive pulmonary hemorrhage and renal glomerulonephritis
How will Goodpasture Syndrome present?
- Hemoptysis, respiratory distress
- Nephritic syndrome – Hematuria, AKI, HTN
What will be seen on immunofluorescence with Goodpasture Syndrome?
LINEAR Anti-GBM deposits
