Leukemia/Lymphoma Flashcards
With an Acute Leukemia, what cells predominate in the blood/BM?
> 20% BLASTS
With a Chronic Leukemia, what cells predominate in the blood/BM?
Mature cells – NOT blasts
What specific finding in the cells will be seen with Acute Myeloid Leukemia?
Auer rods
How do you treat AML with Auer rods?
ATRA – All trans retinoic acid
What marker will be positive with Acute Myeloid Leukemia?
MPO (+)
What markers (2) will be positive with Acute Lymphocytic Leukemia?
Tdt
CaLLa
Acute Lymphocytic Leukemia has a predilection for the CNS. What should be given in addition to chemo/radiation?
ARA-c for CNS disease
What translocation is present with Chronic Myeloid Leukemia?
9;22 = BCR-ABL fusion
What translocation is present with Chronic Myeloid Leukemia?
9;22 = BCR-ABL fusion
The BCR-ABL fusion creates a tyrosine kinase protein for CML. What is the specific treatment?
Imatinib (TK inhibitor)
If a patient has NONtender LAD, what is the best next step?
Excisional biopsy
Following an Excisional biopsy for NONtender LAD, what 3 things need to be done to stage?
CXR
CT abdomen/pelvis/chest
BM biopsy
What cells are seen with Hodgkin’s Lymphoma?
Reed Sternberg cells
= Bi-lobed Nuclei
Lymphomas often present with what?
NONtender LAD
What are the B symptoms?
Fever
Night sweats
Weight loss
Pruritus