Neoplastic Disorders (week 10) Flashcards
neoplastic disease
includes many different diseases that occur due to accumulation of genetic changes due to heredity, environment, and behavior
what is a tumor
overgrowth of tissue independent to the controls that govern cell division and serves no use to the body
neoplasm
new tumor growth
what does cancer refer to
malignant tumor (aggressively expands and metastasizing)
characteristics of benign tumors
slow growers not invasive to other tissues encapsulated cells do not divide rapidly do not metastasize
characteristics of malignant tumors
grow rapidly no encapsulation rapid cell division metastasize invasive to local tissue cross basement membranes
basement membrane
connective tissue structure that holds cells together, usually for a particular organ
carcinogenesis
initiation of cancer
multistage process
4 stages of carcinogenesis
initiation
promotion
transformation
progression
initiation
cell undergoes irreversible mutation
promotion
mutated cell divides and produces a tumor
transformation
mutated cells become cancerous (cells break off and metastasize)
progression
cell proliferation and tumor invasion into tissues
carcinoma
arising from epithelial tissue
adenocarcinoma
arising from ductal or glandular tissue