Neoplasia (incomplete) Flashcards

1
Q

What is a neoplasm?

A

A new growth which doesn’t obey the laws of normal tissue growth and increases in size, persisting at the expense of the rest of the body.

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2
Q

What is the name for a new growth that doesn’t obey the laws of normal tissue growth and increases in size, persisting at the expense of the rest of the body?

A

Neoplasm.

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3
Q

What does cancer literally mean?

A

Crab - to move sideways or to spread.

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4
Q

Define cancer.

A

Cells which grow and divide with decreased restraint or control. Cells do not differentiate normally and therefore don’t function normally or die on time.

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5
Q

What kind of cells grow and divide with decreased restraint and control and do not differentiate normally and therefore don’t function normally or die on time?

A

Cancer cells.

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6
Q

What is a tumour?

A

Swelling, any kind of swelling is referred to as a tumour (infection, trauma, noeplasia).

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7
Q

What is tumour synonymous with in pathology?

A

Neoplasm.

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8
Q

What is neoplasm synonymous with?

A

Tumour (pathology).

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9
Q

What are the two divisions of neoplasms?

A

Benign and malignant tumours.

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10
Q

Define benign tumours.

A

Not fatal/innocent growths.

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11
Q

Define malignant tumours.

A

Fatal growths.

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12
Q

Define metastasis.

A

Spreading of cancer cells to distant organs.

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13
Q

Neoplastic proliferation of cells are:

A
  1. Progressive
  2. No regular arrangement.
  3. Compressing the surrounding tissue.
  4. Not related to the needs of the body.
  5. Parasitic.
  6. Autonomous in its development.
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14
Q

How are tumours named?

A

By adding the suffix -oma to the parenchymal tissue type from which the growth originated.

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15
Q

Define carcinoma.

A

Malignant tumour of the epithelial tissue origin.

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16
Q

Define sarcoma.

A

Malignant tumour of the mesenchymal origin.

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17
Q

Define proliferation.

A

The process by which cells divide and form new daughter cells.

18
Q

What is cell differentiation?

A

The process whereby cells are transformed into different and more specalised cell types.

19
Q

The higher the specialisation of a cell, the lower the ability to divide. True or False?

A

True.

20
Q

The higher the specialisation of a cell, the higher the ability to divide. True or false?

A

False, the higher the specialisation of a cell, the lower the ability to divide.

21
Q

What do cells lose when they differentiate back from higher to lower forms?

A

Their specailised ability (the become more primative).

22
Q

What do cells gain when they differentiate back from higher to lower forms?

A

The ability to divide faster.

23
Q

What three things does differentiation determine?

A
  1. What the cell looks like.
  2. How the cell functions.
  3. How long the cell will live.
24
Q

What are the characteristics of benign tumours?

A
  1. Well defined margin.
  2. Encapsulated.
  3. Grow locally.
  4. Grow slowly and progressively.
  5. Expansive.
  6. Resemble cells of tissue origin.
24
Q

What type of tumour has well defined margins, grows slowly, locally and progressively, and resembles cells of tissue origin?

A

Benign tumour.

25
Q

What are the characteristics of malignant tumours?

A
  1. Poorly defined margins.
  2. Grow rapidly into surrounding tissue.
  3. Destroy surrounding tissue.
26
Q

What type of tumour had poorly define margins, grows rapidly into surrounding tissue and destroys surrounding tissue?

A

Malignant tumour.

27
Q

NEED TO INSERT CARD ON BENIGN/MALIGNANT DIFFERENTIATION

A
28
Q

When do mutations probably develop?

A

During differentiation.

29
Q

What happens when mutation occurs early in the differentiation process?

A

Poorly differentiated and highly malignant.

30
Q

What happens when mutations occur later in the differentiation process?

A

More fully differentiated and less malignant.

31
Q

NEED TO INSERT MORE ON BEHAVIOURAL CHARACTERISTICS.

A
32
Q

What are two important factors in assessing the prognosis in an individual case of cancer?

A

Grading (the histological appearance) and staging (the size and extent of spread of a tumour ).

33
Q

What are the grades of neoplasms?

A

Grade I - well differentiated
Grade II - moderately differentiated
Grade III - poorly differentiated
Grade IV - extremely anaplastic

34
Q

What does the acronym TNM stand for and assess?

A

Tumour (extent of primary tumours), node (regional lymph nodes involvement), metastasis (extent of metastatic involvement).

35
Q

What is the staging of tumours in the TNM classification?

A
TX - tumour cannot be assessed
T0 - no evidence of primary tumour
TIS - carcinoma in situ
T1 - lesion < 2 cm
T2 - lesion 2 - 5 cm
T3 - skin involve
36
Q

What is the staging of nodes in the TNM classification?

A

NX - Regional lymph nodes cannot be assessed
N0 - No evidence of regional lymph node metastasis
N1 - Mobile nodes involved
N2 - Fixed nodes involved

37
Q

What is the staging of metastasis in the TNM classification?

A

MX - Not assessed
M0 - No distant metastasis
M1 - distant metastasis present

38
Q

By what three means can cancer spread?

A
  1. Direct invasion and extension.
  2. Seeding of cancer cells within body cavities.
  3. Metastasis through blood or lymph.
39
Q

NEED TO ADD SPECIFICS OF MEANS OF SPREADING CANCER and everything following that

A