Neoplasia

Question 1

List the features of dysplasia

Answer 1

• Variation in shape and size of cells
• variation shape and size of nuclei: enlargement, irregularity and hyperchromatism of nuclei
• tldr: cellular and nuclear pleomorphisms

Question 2

List the 4 characteristics that help differentiate between benign and malignant neoplasms

Answer 2

1. Differentiation and anaplasia
2. Rate of growth
3. Invasion
4. Metastasis

Question 3

Microscopic features of anaplastic malignant cells:

Answer 3

• variable cell size and shape
• variable nuclear size and shape
• ↑ nuclear: cytoplasmic ratio
• hyperchromatic nuclei
• increased and abnormal mitosis
• tumor giant cell

Question 4

Name an exception to the rule that benign tumors are slow growing

Answer 4

Leiomyoma during pregnancy

Question 5

Poorly differentiated tumor has a _______ rate of growth

Answer 5

Fast; can undergo necrosis due to fast rate

Question 6

Proliferation marker for rate of growth of a tumor

Answer 6

Ki67