DLA Adverse Effects

Question 1

Ginkgo biloba is contraindicated when taken with _________

Answer 1

NSAIDs (other platelet aggregation inhibitors)

Question 2

What should you NOT take with herbs that contain St. John’s Worts?

Answer 2

SSRI’s (other antidepressants)

Question 3

Examples of acute toxicity

Answer 3

Hepatic necrosis after single toxic dose of acetominophen and immune mediated adverse effects

Question 4

Drugs that can cause pulmonary fibrosis

Answer 4

Amiodarone (antiarrhythmic)

Bleomycin

Question 5

Define and give an example of an on target adverse effect

Answer 5

On target effect is an exaggeration of the desired pharmacologic action of the drug OR if the intended receptor is activated but in a non target tissue
Ex. Hypoglycemia caused by insulin;

Question 6

Define and give an example fo an off target adverse effect

Answer 6

Activation of an incorrect receptor in target or non target tissue
Ex. If a drug targets histamine receptors but also has an affinity for potassium channels
Enantiomers can cause off target effects
Unintended actuation of different receptor subtypes