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Systemics- GI > Neoplasia > Flashcards

Neoplasia Flashcards

1
Q

Difference between conventional ameloblastoma and canine acanthomatous ameloblastoma; locations?

A

Conventional ameloblastoma has stellate reticulum, CAA does not; CA on maxilla, CAA on rostral mandible

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2
Q

Difference between CA/CAA and odontoameloblastoma?

A

ODA is inductive- has majority OE with SR, but also has PDL-like stroma pulp ectomesenchyme, enamel, and dentin

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3
Q

Virus associated with hepatocellular carcinoma? In what species?

A

Hepadnaviridae (dsDNA); woodchuck, NHPs

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4
Q

Where does hepadnavirus integrate?

A

c-myc or n-myc2 locus

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5
Q

Key histo for hepatocellular carcinoma

A

Trabecular most common, pseudoglandular (adenoid), solid

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6
Q

IHC for hepatocellular carcinoma

A

HepPar1

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7
Q

Difference between cutaneous mast cell tumors and GI mast cell tumors; IHC

A

Mucosal origin, lack IgE and chymase, less histamine (less ulcers); cKIT (CD117)

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8
Q

Where are GI mast cell tumors most common

A

Stomach

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9
Q

Key histo for GI mast cell tumors

A

Poorly staining granules, 33% of feline GI mast cell tumors do not stain with cKIT

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10
Q

Who gets GI adenocarcinoma? Where?

A

Rhesus- ileocecal and colon
Cotton-topped tamarins- colon

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11
Q

Why do cotton topped tamarins get colonic adenocarcinoma?

A

Sequelae to ulcerative colitis

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12
Q

Characteristic gross appearance of GI adenocarcinoma

A

Annular ring-like thickening

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13
Q

Most common histologic appearance of GI adenocarcinoma?

A

Scirrhous and mucin producing
Tubular/acinar
Anaplastic
Signet rings

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14
Q

Four main morphologic patterns of pancreatic adenocarcinoma

A

Small tubular**, large tubular, acinar, hyalinizing

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15
Q

What is pancreatic adenocarcinoma associated with?

A

Diabetes mellitus, nitrosamines, pancreatitis

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16
Q

What paraneoplastic syndrome is associated with pancreatic adenocarcinoma?

A

In cats, paraneoplastic alopecia

17
Q

Who is predisposed to AGASACA?

A

Old intact female or neutered male dogs

18
Q

What paraneoplastic syndrome with AGASACA

A

Paraneoplastic hypercalcemia caused by PTHrp

19
Q

IHC profile for AGASACA

A

CK7, BCL-2 positive
CK14 negative

20
Q

Syndrome associated with carcinoids

A

Zollinger-Ellison syndrome- secrete gastrin, cause gastric hypersecretion and ulceration

21
Q

How to diagnose carcinoids

A

Neurosecretory granules on TEM
IHC- synaptophysin, NSE, CgA

22
Q

Most common gastric tumor in the horse? What is it associated with?

A

Squamous cell carcinoma; EcPV2

23
Q

Most common oral tumor in cats?

A

Squamous cell carcinoma

24
Q

Clin path findings with SCC

A

Hypercalcemia, anemia, hypoalbuminemia

25
Q

What is SCC associated with in snakes and turtles?

A

Herpesvirus

26
Q

What is cholangiocarcinoma associated with? Classic gross appearance?

A

Flukes; umbilicated

27
Q

Positive IHCs for cholangiocarcinoma

A

CK7, CK14, CK19

28
Q

What causes choanal papilloma in parrots and macaws? Cholangiocarcinoma?

A

Psittacid herpesvirus (PsHV) 1, 2, 3; herpesvirus 1

29
Q

In which species is salivary adenocarcinoma more aggressive? Which glands?

A

Cats; Parotid and submandibular

30
Q

Stains for mucus

A

Mucicarmine, Alcian blue, PAS

31
Q

Who gets salivary gland myoepitheliomas? Which glands?

A

BALB mice; Submaxillary and parotid salivary glands

32
Q

What other findings are observed with salivary gland myoepithelioma in mice?

A

Myeloid hyperplasia of bone marrow and spleen

33
Q

What type of organism is Eimeria tenella/macusaniensis? EM findings?

A

Apicomplexan protozoan; conoid, micronemes, rhoptries

34
Q

Most pathogenic Eimeria in chickens? Location? Camelids? Location?

A

Eimeria tenella; cecum
Eimeria macusansiensis; jejunum/ileum

35
Q

Key gross with Eimeria tenella; key histo

A

Fibrinonecrotic cecal core; Fibrinonecrotic typhlocolitis, villous atrophy, erosion; oocysts, schizonts with merozoites, macrogamonts, microgamonts

36
Q

EImeria stiedae affects which species? Location?

A

Weanling rabbits; bile duct epithelium

37
Q

Key histo with Eimeria stiedae?

A

Biliary hyperplasia, dilated bile ducts, gametocytes, schizonts, and oocysts in ducts

Systemics- GI (8 decks)

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