Neonatal Lupus

Question 1

Who is at risk?

Answer 1

Infants of mothers who have anti-SSA/Ro antibodies

Question 2

What are the cutaneous features of neonatal lupus?

Answer 2

Annular erythematous plaques

Predilection for the face, especially the periorbital region and scalp

Photosensitive

Resolve without scarring
- Dyspigmentation can cont for months.

Question 3

What are the assocations with neonatal lupus?

Answer 3

Congenital heart block (+/- cardiomyopathy)
- almost always present by birth, but on rare occasions has developed after birth

Hepatobiliary disease
- can vary in severity
- liver failure during gestation or in the neonatal period
- conjugated hyperbilirubinemia during the first few weeks of life –> mild elevations of aminotransferases at 2–3 months of life.

Cytopenias
- thrombocytopaenia

Hydrocephalus, microangiopathic haemolysis, and disseminated intravascular coagulation.