Melanoma Flashcards
Types of immunotherapy for melanoma
Options for RX of desmoplastic melanoma
Radiotherapy
Poor prognostic mutations in melanoma
NRAS
CKIT
What is the benefit of adding MEK to BRAF inhibitors?
Improved survival
Fewer side effects
What else do you use BRAF inhibitors for?
Histiocytosis (langerhan cell)
Others…
Which subtype of melanoma responds well to radiotherapy?
Desmoplastic
Tumour staging of melanoma and how it influences management
Tis - melanoma in situ
T1
A) <0.8 with ulceration
B) 0.8 - 1 without ulceration
T2
A) 1 - 2 mm with ulceration
B) 1 - 2 mm without ulceration
T3
2 - 4 mm
T4
4 mm
Tumour staging of melanoma and how it influences management
Tis - melanoma in situ
T1
A) <0.8 with ulceration
B) 0.8 - 1 without ulceration
T2
A) 1 - 2 mm with ulceration
B) 1 - 2 mm without ulceration
T3
2 - 4 mm
T4
4 mm
How does tumour stage affect melanoma margins?
Mis: 5mm margins, LM consider 1cm
T1: 1 cm margins
T2: 2 cm margins
T3: 2cm margins
T4: 2 cm margins
Are margins clinical or hsitological?
Studies are clinical
How do you biopsy a melanoma?
Excisional with 2mm margins
Or mapping biopsies
Avoid shave where possible
