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.Medical Dermatology > Amyloidosis > Flashcards

Amyloidosis Flashcards

1
Q

Descibe. This tissue has a toludine blue and alkaline fuchsin stain

A
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2
Q

This tissue has been stained with Thioflavin

A
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3
Q

Describe

A

Amorphous mass of eosinophillic material with the superficial dermis

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4
Q

Differenitation between nodular PCLA and systemic amyloidosis may require biopsies taken from the rectal submucosa or abdominal subcutaneous fat

A

True

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5
Q

What stains can you do if you suspect amyloidosis

A

Standard stains:
- H +E,
- toludine blue
- alkaline fuschsin
- PAS (positive)

Amyloid stains:
- Congo Red (apple green birefingrince under polarised light)
- Thioflavin T (positive immunoflurescence)
- Crystal violet or methyl violet (metachromasia)

Immunohistochemistry:
- Cytokeratin stains (pan or for 5, 1, 10 and 14)
- immunoglobulin light chain antibodies

Electronmicroscopy

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6
Q
A
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7
Q

Other than stains, what else can you do with a skin sample suspicious for amyloidsosis?

A

Electron microscopy - can visualise amyloid fibrils and filaments ( 7.5 - 10 nm)

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8
Q

What the triggers for amyloidosis?

A

○ Chronic inflammation
○ Malignancy
○ Mutation
○ Pro-amyloidogenic peptides sequences
○ Microenvironmental changes

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9
Q

How do you classify amyloidsosis?

A
  • Primary localised cutaneous amyloidosis (PLCA)
  • Secondary localised cutaneous amyloidosis (SLCA)
  • Systemic amyloidosis with cutaneous involvement
  • Secondary cutaneous amyloidosis originating from other systemic disease
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10
Q

How do you investigate someone you suspect has primary cutaneous amyloidosis?

A

Biopsy for:
- HE, toluidine blue, alkaline fuchin
- congo RED, thioflavin T, crystal violet, methyl violet
- IF: cytokeratin, immunoglobulin light chians
- Electronmicroscopy

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11
Q

What are the investigations for systemic amyloidosis?

A

Baseline:
- FBC
- UEC
- Urinalysis
- Coagulation profile
- BNP
- Troponin
- ECG

Abdominal fat +/- direct tissue biopsy for all suspected systemic amyloidsosis systems

Immunotyping

SPEP, urine electophoresis

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12
Q

Describe and provide DDx

A
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13
Q

Describe

A
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14
Q

What are the subtypes of Localised cutaneous amyloidosis

A

Papular (lichenoid) PLCA (35%)
Macular PLCA (35%)
Nodular PLCA (1.5%)

Secondary localised cutaneous amyloidosis SLCA

Familial PLCA

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15
Q

Primary cutaneous amyloidosis affects women more than it affects men

A

True (2-3 -1)

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16
Q

Describe and DDx

17
Q
A

Describe and Dx

18
Q
A

Describe and DDx

19
Q

Describe and Dx

20
Q

Describe and Dx

21
Q

Describe and Dx

23
Q

Describe and Dx

.Medical Dermatology (23 decks)

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